Page 52 - MI-2-1

Microbes & Immunity iPSC-derived NK cell immunotherapy

2015;10(3):e0121788. 148. Cubitt CC, McClain E, Becker-Hapak M, et al. A novel fusion
protein scaffold 18/12/TxM activates the IL-12, IL-15, and
doi: 10.1371/journal.pone.0121788
IL-18 receptors to induce human memory-like natural killer
142. Srpan K, Ambrose A, Karampatzakis A, et al. Shedding cells. Mol Ther Oncolytics. 2022;24:585-596.
of CD16 disassembles the NK cell immune synapse
and boosts serial engagement of target cells. J Cell Biol. doi: 10.1016/j.omto.2022.02.009
2018;217(9):3267-3283. 149. Zhu H, Blum RH, Bernareggi D, et al. Metabolic
reprograming via deletion of CISH in human iPSC-derived
doi: 10.1083/jcb.201712085
NK cells promotes in vivo persistence and enhances anti-
143. Wagner JA, Rosario M, Romee R, et al. CD56bright NK cells tumor activity. Cell Stem Cell. 2020;27(2):224-237.e6.
exhibit potent antitumor responses following IL-15 priming. doi: 10.1016/j.stem.2020.05.008
J Clin Invest. 2017;127(11):4042-4058.
150. Hanna J, Wald O, Goldman-Wohl D, et al. CXCL12
doi: 10.1172/JCI90387 expression by invasive trophoblasts induces the specific
144. Wu Z, Xu Y. IL-15Rα-IgG1-Fc enhances IL-2 and IL-15 anti- migration of CD16- human natural killer cells. Blood.
tumor action through NK and CD8 T cells proliferation 2003;102(5):1569-1577.
+
and activation. J Mol Cell Biol. 2010;2(4):217-222. doi: 10.1182/blood-2003-02-0517
doi: 10.1093/jmcb/mjq012 151. Barlic J, McDermott DH, Merrell MN, Gonzales J, Via LE,
145. Kobayashi H, Carrasquillo JA, Paik CH, Waldmann TA, Murphy PM. Interleukin (IL)-15 and IL-2 reciprocally
Tagaya Y. Differences of biodistribution, pharmacokinetics, regulate expression of the chemokine receptor CX3CR1
and tumor targeting between interleukins 2 and 15. Cancer through selective NFAT1- and NFAT2-dependent
Res. 2000;60(13):3577-3583. mechanisms. J Biol Chem. 2004;279(47):48520-48534.
146. Fujii R, Jochems C, Tritsch SR, Wong HC, Schlom J, doi: 10.1074/jbc.M406978200
Hodge JW. An IL-15 superagonist/IL-15Ralpha fusion 152. Sechler JM, Barlic J, Grivel JC, Murphy PM. IL-15 alters
complex protects and rescues NK cell-cytotoxic function expression and function of the chemokine receptor CX3CR1
from TGF-beta1-mediated immunosuppression. Cancer in human NK cells. Cell Immunol. 2004;230(2):99-108.
Immunol Immunother. 2018;67(4):675-689.
doi: 10.1016/j.cellimm.2004.10.001
doi: 10.1007/s00262-018-2121-4
153. Velasquez SY, Killian D, Schulte J, Sticht C, Thiel M,
147. Lee TT, Li YE, Bjordahl R, et al. Abstract 3574: Cytokine- Lindner HA. Short term hypoxia synergizes with interleukin
autonomous, CAR-directed, off-the-shelf natural killer cells 15 priming in driving glycolytic gene transcription and
derived from a clonal engineered master pluripotent cell supports human natural killer cell activities. J Biol Chem.
line. Cancer Res. 2018;78(13_Supplement):3574. 2016;291(25):12960-12977.
doi: 10.1158/1538-7445.AM2018-3574 doi: 10.1074/jbc.M116.721753

Volume 2 Issue 1 (2025) 44 doi: 10.36922/mi.5653