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Materials Science in

                                                                  Additive Manufacturing



                                        REVIEW ARTICLE
                                        Metal additive manufacturing of orthopedic

                                        bone plates: An overview



                                        Weiting Xu, Aydin Nassehi, and Fengyuan Liu*
                                        School of Electrical, Electronic and Mechanical Engineering, University of Bristol, Bristol, United Kingdom



                                        Abstract

                                        Orthopedic bone plates, traditionally made from materials such as stainless steel
                                        or titanium alloy, have been pivotal in treating fractures. However, the disparity in
                                        modulus between these metals and natural bone leads to challenges, especially
                                        stress shielding, which can hinder optimal healing and cause issues such as bone
                                        resorption. In addition, the increase in complex fractures due to osteoporosis and
                                        demographic changes also points to the limitations of standard bone plates. This
                                        evolving landscape underscores the growing need for patient-specific solutions. This
                                        review delves into the advantages and challenges concerning the material choice,
                                        design, and production processes for the additive manufacturing (AM) of bone
                                        plates. AM offers the potential to customize bone plates using detailed computerized
                                        tomography scans or topology optimization, paving the way for unparalleled
                                        customization and potentially more effective bone regeneration. However, the
                                        intricacies of AM, from choosing the right materials to final production, add layers
                                        of complexity. An innovative methodology in the field of laser-metal Additive
                                        Manufacturing, known as Material-Structure-Performance Integrated AM (MSPI-AM),
            *Corresponding author:      is at the forefront of tackling existing challenges, with the goal of enhancing the
            Fengyuan Liu                overall process in this domain. This strategy seamlessly blends material properties,
            (fengyuan.liu@bristol.ac.uk)
                                        structural  components,  and  functional  performance.  Enriched  by  the analytical
            Citation: Xu W, Nassehi A, Liu F,   capabilities of artificial intelligence, this comprehensive method aims to enhance the
            2023, Metal additive manufacturing
            of orthopedic bone plates: An   AM process. It envisions a future where orthopedic treatments are not just functional
            overview. Mater Sci Add Manuf,   but also are personalized masterpieces that reflect individual patient needs and
            2(4): 2113.                 address a variety of fracture scenarios.
            https://doi.org/10.36922/msam.2113
            Received: October 25, 2023
                                        Keywords: Orthopedic bone plate; Additive manufacturing; Biomaterial; Patient-specific
            Accepted: November 22, 2023  implant; Stress shielding
            Published Online: December 8,
            2023
            Copyright: © 2023 Author(s).
            This is an Open-Access article   1. Introduction
            distributed under the terms of the
            Creative Commons Attribution   Bone fractures represent a significant concern in orthopedics, stemming from
            License, permitting distribution,   various causes such as injuries, osteoporosis, and overuse . Remarkably, the natural
                                                                                       [1]
            and reproduction in any medium,   regenerative capacity of bone tissues allows for a high success rate in fracture healing,
            provided the original work is
                                                                                                [2]
            properly cited.             with approximately 90 – 95% of fractures achieving successful recovery . Nevertheless,
                                        the healing process is complex as it involves a series of interconnected cellular events
            Publisher’s Note: AccScience
            Publishing remains neutral with   over a prolonged time [3-5] .
            regard to jurisdictional claims in
            published maps and institutional   Two primary mechanisms underpin fracture healing are the primary and secondary
                                                      [6]
            affiliations.               healing processes . Primary healing is a direct, although rare, and self-repair process
            Volume 2 Issue 4 (2023)                         1                       https://doi.org/10.36922/msam.2113
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