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EDITORIAL
Organoid research: Advanced models, precision

medicine, and translational medicine

Long Bai 1,2,3 , Rui L. Reis * , Shawn Chen 6,7,8,9,10,11,12,13 * , Jiacan Su 1,2,14 * , and Changsheng Liu 1,15 *
4,5
1 Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, China
2 National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, China
3 Wenzhou Institute of Shanghai University, Wenzhou, Zhejiang, China
4 3B’s Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of
the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Portugal
5 ICVS/3B’s - PT Government Associate Laboratory, Braga, Portugal
6 Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
7 Department of Chemical and Biomolecular Engineering, College of Design and Engineering, National University of Singapore, Singapore
8 Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore
9 Department of Pharmacy and Pharmaceutical Sciences, Faculty of Science, National University of Singapore, Singapore
10 Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore,
Singapore
11 Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
12 Theranostics Center of Excellence (TCE), Yong Loo Lin School of Medicine, National University of Singapore, Singapore
13 Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), Singapore
14 Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
15 Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Center for Biomedical Materials of the Ministry of
Education, East China University of Science and Technology, Shanghai, China
*Corresponding authors: Rui L. Reis (rgreis@i3bs.uminho.pt); Shawn Chen (chen.shawn@nus.edu.sg);
Jiacan Su (drsujiacan@163.com); Changsheng Liu (liucs@ecust.edu.cn)

Citation: Bai L, Reis RL, Chen S, Organoids have taken the biomedical research world by storm. These 3D, miniaturized
Su J, Liu C. Organoid research: versions of human organs, grown from stem cells, have proven to be invaluable models
Advanced models, precision
1,2
medicine, and translational medicine. for studying tissue development, disease progression, and therapeutic interventions.
Organoid Res. 2025;1(1):025060009. Their ability to recapitulate the complexity of human organs, both structurally and
doi: 10.36922/OR025060009 functionally, offers new insights that traditional 2D cell cultures could not. As
3
Received: February 7, 2025 a result, organoid research is now at the forefront of many scientific disciplines,
1,4
Accepted: February 12, 2025 including regenerative medicine, cancer research, and drug discovery. Yet, despite
their tremendous potential, challenges remain in the development of standardized
Published online: February 14, 2025 methods and their successful clinical application. To address these hurdles and
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Copyright: © 2025 Author(s). continue pushing the field forward, we are excited to launch Organoid Research, a
This is an Open Access article journal dedicated to promoting the latest advancements in organoid science.
distributed under the terms of the
Creative Commons Attribution Organoid Research is an international, peer-reviewed journal that publishes high-
License, permitting distribution, and
reproduction in any medium, which quality, cutting-edge research across the entire organoid landscape. The journal’s
provided that the original work is mission is to foster the integration of organoid technologies with clinical and
properly cited. translational applications. The scope of the journal includes, but is not limited to:
Publisher’s Note: AccScience • Development and applications of stem cell-based organoid models
Publishing remains neutral with regard • Bioengineering and biofabrication techniques to enhance organoid functionality
to jurisdictional claims in published • Organoids as tools for disease modeling and drug screening, with a focus on
maps and institutional affiliations.
genetic disorders, cancer, and neurological diseases
• Advances in the use of organoid models for regenerative medicine and tissue
engineering
• The integration of organoid technologies with materiobiology, high-throughput
screening, artificial intelligence, and precision medicine

Volume 1 Issue 1 (2025) 1 doi: 10.36922/OR025060009