Page 8 - OR-1-1

• Exploration of ethical issues and regulatory challenges ethicists, we hope to accelerate the translation of organoid
in clinical organoid translation. technologies into real-world medical solutions.

The inaugural issue of Organoid Research features The future of organoid research holds great promise.
several outstanding contributions that reflect the broad As the field continues to evolve, Organoid Research will
potential of organoid technology. Among them, the review remain committed to advancing knowledge, promoting
by Wu et al. discusses the applications and challenges of innovation, and addressing the challenges that stand in
advanced hydrogels in tissue systems, emphasizing their the way of translating organoids into practical and clinical
role in enhancing organoid development and functionality. applications. We look forward to your engagement and
Another key study by Lin et al. provides a bibliometric and support in advancing the transformative potential of
visualization analysis of global research trends in bone and organoid technologies.
cartilage organoids from 2010 to 2024, offering insights
into the evolving landscape and future directions of this Conflict of interest
field. In addition, Wu et al. explore the integration of 3D The authors declare that they have no competing interests.
bioprinting technology to advance organoid development,
highlighting its potential in creating more physiologically References
relevant tissue models. 1. Rossi G, Manfrin A, Lutolf MP. Progress and potential in
The issue also features innovative research on organoid- organoid research. Nat Rev Genet. 2018;19(11):671-687.
based drug screening. Su et al. introduce a cartilage- doi: 10.1038/s41576-018-0051-9
on-chip model for osteoarthritis drug screening, which 2. Clevers H. Modeling development and disease with
represents a promising approach for identifying effective organoids. Cell. 2016;165(7):1586-1597.
therapeutics for joint diseases. Moreover, Zhang et al.
present the “2024 Organoids Breakthrough of the Year,” doi: 10.1016/j.cell.2016.05.082
showcasing the most significant advancements that have 3. Kratochvil MJ, Seymour AJ, Li TL, Paşca SP, Kuo CJ,
shaped organoid research and its biomedical applications. Heilshorn SC. Engineered materials for organoid systems.
Furthermore, ethical and theoretical considerations are Nat Rev Mater. 2019;4(9):606-622.
addressed in a mini-review by Liu et al., which examine doi: 10.1038/s41578-019-0129-9
the fundamental principles, emerging technologies, and 4. Broutier L, Mastrogiovanni G, Verstegen MM, et al. Human
therapeutic prospects of organoid research, providing primary liver cancer-derived organoid cultures for disease
a comprehensive perspective on the field’s future. This modeling and drug screening. Nat Med. 2017;23:1424-1435.
collection of studies underscores the rapid progress in doi: 10.1038/nm.4438
organoid research, from technological innovations to
biomedical applications, and highlights the challenges and 5. Quadrato G, Brown J, Arlotta P. The promises and challenges
opportunities that lie ahead in harnessing organoids for of human brain organoids as models of neuropsychiatric
translational medicine. disease. Nat Med. 2016;22(11):1220-1228.
doi: 10.1038/nm.4214
Organoid Research aims to serve as a central platform
for the dissemination of high-quality, interdisciplinary 6. Veninga V, Voest EE. Tumor organoids: Opportunities
research that bridges the gap between basic organoid science and challenges to guide precision medicine. Cancer Cell.
and clinical application. By encouraging collaboration 2021;39(9):1190-1201.
between bioengineers, stem cell biologists, clinicians, and doi: 10.1016/j.ccell.2021.07.020

Volume 1 Issue 1 (2025) 2 doi: 10.36922/OR025060009