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REVIEW ARTICLE
Global research trends in bone/cartilage organoids

from 2010 to 2024: A bibliometric and visualization
study

Aikang Li 1,2† , Rongji Liang 1,3† , Weibei Sheng 2† , Xiaohao Wu 4 , Weijin Guo 5 , Peng Liu 6 , Hui Zeng 7 ,
Liang Gao * , Fuyang Cao * , Yanbin Peng *, and Jianjing Lin *
11
10
3
8,9
1 Shantou University Medical College, Shantou University, Shantou, Guangdong, China
2 Department of Orthopedics, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
3 Department of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
4 Division of Immunology and Rheumatology, School of Medicine, Stanford University, Palo Alto, California, United States of America
5 Department of Biomedical Engineering, Shantou University, Shantou, Guangdong, China
6 National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen,
Guangdong, China
7 Department of Orthopedics, Shenzhen Second People’s Hospital (First Affiliated Hospital of Shenzhen University), Shenzhen, Guangdong,
China
8 Berlin Center of Clinical Medicine, Huatuo Insitute of Medical Innovation (HTIMI), Berlin, Germany
9 Department of Clinical Research and Development, Benovus Medical Technology (BMT) Corporation, Chengdu, China
10 Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
11 Department of Hand & Microsurgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
† These authors contributed equally to this work.
*Corresponding authors: Liang Gao (lianggao22@gmail.com); Fuyang Cao (drcao0603@163.com); Yanbin Peng (p1y1b1@163.
com); Jianjing Lin (linjianjing@bjmu.edu.cn)

Citation: Li A, Liang R, Sheng W, Abstract
et al. Global research trends in bone/
cartilage organoids from 2010 to
2024: A bibliometric and visualization Bone/cartilage organoids have garnered significant attention in regenerative
study. Organoid Res. 2025;1(3):8295. medicine due to their promising applications in tissue repair and disease modeling.
doi: 10.36922/or.8295 Despite this growing interest, there is still a gap in understanding global research
Received: September 30, 2024 trends and developments in this field. This study provides a comprehensive review
of the present status and emerging directions of bone/cartilage organoid research
Revised: October 20, 2024
worldwide. Utilizing data from 288 records in the Web of Science Core Collection
Accepted: January 23, 2025 (2010 – 2024), we employed R, VOSviewer, CiteSpace, and GraphPad Prism to
Published online: April 16, 2025 analyze the literature’s historical development, general characteristics, and keyword
distributions. The analysis revealed a steady increase in publications since 2010,
Copyright: © 2025 Author(s).
This is an Open-Access article peaking in 2023, with the United States leading in contributions, and Bioactive
distributed under the terms of the Materials as the most influential journal. Noteworthy authors included Jiacan Su from
Creative Commons Attribution China and Hans Clevers from the Netherlands. Research subareas were clustered into
License, permitting distribution, and
reproduction in any medium, which seven themes: Regenerative Medicine, Bone Regeneration, Bone Marrow Organoids,
provided that the original work is Differentiation, Extracellular Matrix, Expression, and Protein-Based Culture. Four
properly cited. main research directions were identified: stem cells and the microenvironment,
Publisher’s Note: AccScience biomaterials, regenerative medicine, and disease modeling/drug screening. This
Publishing remains neutral with regard first bibliometric study on bone/cartilage organoids establishes a knowledge map,
to jurisdictional claims in published
maps and institutional affiliations. identifies key trends, and pinpoints potential hotspots, offering valuable insights for
future research in this evolving field.

Keywords: Bibliometric; Visualization; Bone/cartilage organoids; Tissue
engineering

Volume 1 Issue 3 (2025) 1 doi: 10.36922/or.8295