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The bibliometric analysis of bone/cartilage organoid Table 1 lists the top five authors in bone/cartilage organoid
research highlighted significant collaboration networks research based on their publication output.
among countries and institutions, with the USA and Publications, defined as the minimum number of
China emerging as dominant contributors (Figure 4). documents authored by an individual (>2), were contributed
Countries such as Germany, the United Kingdom, and the by 132 authors and subsequently analyzed using VOSviewer.
Netherlands formed additional clusters, demonstrating As shown in Figure 5A, the co-authorship network reveals
frequent cooperation both within Europe and beyond a highly collaborative group of researchers, primarily based
(Figure 4A and 4C). At the institutional level, Shanghai in China, within the bone/cartilage organoid research field.
Jiao Tong University served as a major research hub, Key figures such as Jiacan Su, Peiran Song, and Jian Wang
collaborating extensively with prominent institutions, such are central to the network, indicating their significant roles
as Harvard Medical School and the University of Michigan in advancing this area of study. Figure 5B illustrates the
(Figure 4B and 4D). These institutions, along with others relationships between authors based on shared references,
within their respective clusters, established robust partnerships forming distinct clusters around Hans Clevers, Jiacan Su,
that are crucial for advancing research in the field.
and Magali Demoor. Jiacan Su (China) was linked to key
Further examples of international collaboration include researchers, such as Shuichi Mizuno (Japan) and Frank P.
Cincinnati Children’s Hospital Medical Center (USA) Luyten (Belgium), highlighting global collaboration across
and Tokyo Medical and Dental University (Japan), whose China, Europe, and Japan in bone/cartilage organoid
work combining organoid technology with organ-on- research. The co-citation analysis (Figure 5C) identified
a-chip engineering underscored the potential of these three main clusters of frequently cited researchers. The red
technologies in regenerative and precision medicine. cluster, led by Lancaster MA and Takasato M, focused on
25
Similarly, the partnership between the University of bone and cartilage organoid research, particularly in disease
Toronto (Canada) and Yokohama City University (Japan) modeling and regenerative strategies. Lancaster MA’s work
demonstrated a commitment to advancing organoid in modeling human development and disease has provided
complexity and functionality through principles derived valuable insights into potential therapeutic applications. 27,28
from organogenesis, enhancing tissue modeling for diverse The purple cluster, centered around T Sato and including
biomedical applications. 26 prominent figures such as N Barker and Hans Clevers,
reflected foundational contributions to the field. Hans
3.3. Bibliometric analysis of global leading authors Clevers discussed the principles of stem cell biology and the
Analyzing authors can identify key figures that are potential for growing mini-organs from stem cells in vitro,
representative of a field and serve as its core contributors. advancing our understanding of organoid development.
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A B

C D

Figure 4. Bibliometric analysis of different countries and institutions. (A) Bibliographic coupling analysis of 19 countries in the field of bone/cartilage
organoid research. (B) Bibliographic coupling analysis of 32 institutions involved in bone/cartilage organoid research. (C) Network visualization of
co-authorship relationships among countries. (D) Network visualization of co-authorship relationships among institutions. Notes: The size of each node
represents the number of publications, while the lines between nodes indicate cooperative relationships; the thickness of the lines reflects the degree
of collaboration. Different colors signify distinct clusters, whereas nodes of the same color represent countries and institutions that collaborate more
frequently and closely.

Volume 1 Issue 3 (2025) 5 doi: 10.36922/or.8295