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Table 2. The top five journals in bone/cartilage organoids based on publication output
Rank Journal Documents Citations Average article citation H‑index
1 Stem Cell Research and Therapy 9 104 11.56 4
2 Biofabrication 7 231 33 5
3 Frontiers in Cell and Developmental Biology 7 28 4 2
4 International Journal of Molecular Sciences 7 43 6.14 5
5 Bioactive Materials 6 226 37.67 5

A B

C

Figure 6. Bibliometric analysis of leading global journals. (A) Bibliographic coupling analysis of journals on bone/cartilage organoids. (B) Mapping of
co-cited journals. (C) Analysis of citation bursts within journals. The blue horizontal lines represent the duration and intensity of attention each category
received over time, with longer lines indicating greater popularity.

indicating its consistent role in advancing the technologies et al., reflecting ongoing research into scaffold structures
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and methods essential for organoid development and and advanced biomaterials for organoid development.
repair, particularly in soft tissue regeneration. The green cluster centers on cellular and genetic studies,
To visualize the distribution of citing and cited which are crucial for advancing stem cell research and
journals, we used a dual-map overlay. As shown in organoid modeling. 33-35 The blue cluster emphasizes
Figure 7, citing journals are predominantly clustered in methodologies, exploring innovative techniques to
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fields, such as Molecular Biology, Immunology, Medicine, improve organoid culture systems. Finally, the yellow
Clinical Sciences, and Veterinary Science, represented by cluster focuses on the genetic mechanisms underlying
yellow, green, and purple clusters. On the right side, the organoid formation, particularly the genetic pathways
most frequently cited fields include Molecular Biology, and molecular signals that guide tissue organization and
39-41
Genetics, Health, Nursing, Medicine, and Biomaterials. differentiation.
A notable citation link exists between Molecular Biology, Cited publications related to bone/cartilage organoid
Immunology, and Health, Nursing, and Medicine, research were further analyzed by examining the most
underscoring the significant impact of biological sciences influential papers from 2010 to 2024. The top three papers
on clinical and medical research. with citation bursts were identified using VOSviewer
(Figure 8B). The first reference, titled “The horizon of bone
3.5. Bibliometric analysis of highly cited references organoid: A perspective on construction and application”
The co-citation map illustrates a network of highly (2022), exhibited the highest burst strength of 2.92.
co-cited literature. Out of 18,238 references, 178 articles This review introduced the research progress of bone
were cited more than five times and are displayed in organoids and proposed strategies for their construction,
Figure 8A. These articles are grouped into four major study directions, and application prospects. The second
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clusters, each represented by a distinct color. The red paper, titled “Developmentally engineered callus organoid
cluster contains studies focused on materials science and bioassemblies exhibit predictive in vivo long bone healing”
biomaterials, such as those by Moroni et al. and Nilsson (2020), had burst strength of 2.79. This research focused
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Volume 1 Issue 3 (2025) 7 doi: 10.36922/or.8295