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Tumor Discovery A bioinformatics analysis of PD-1 in cancers

Figure 3. Prognostic value of PD-1 mRNA expression in ovarian cancer patients. Abbreviation: HR, hazard ratio.

promoting the development of tumors . In our work, we tissues in patients with epithelial ovarian cancer is related to
[25]
found that low PD-1 expression is a poor prognostic factor malignant progression of tumors . These results indicate
[27]
for relapse-free, progression-free, OS, and disease-specific that the expression of PD-1 on the surface of immune cells
survival rates. is also important to the ovarian cancer microenvironment.
Tan et al. showed that PD-1 expression on the surface of In our analysis, PD-1 expression was negatively related
[26]
ovarian cancer cells was positively correlated with the degree to the PFS rate of ovarian cancer patients, but positively
of tumor differentiation. In addition, PD-1 expression on the associated with the OS and PPS rates. The paradoxical results
surface of T cells in patients with malignant ovarian tumors may be attributable to several reasons: (i) differences in
was also significantly increased. The expression of PD-1 detection methods used and population studied; (ii) tissue
protein in ovarian cancer tissue is significantly higher than specificity; and (iii) antibodies of different clone numbers
that of cancer. The PD-1 protein expression level in the cancer located in different tissues. Gene expression regulation
tissue of Stage I-II and Grade 1-2 patients was significantly includes regulation at the transcriptional level, mRNA
lower than that in stage III-IV and Grade 3 patients. The processing, regulation at the maturation level, and regulation
3-year survival rate of the patients with high PD-1 expression at the translational level. Post-transcriptional regulation,
was significantly lower than that of the patients with low translation and post-translational regulation all contribute to
expression. In summary, PD-1 protein expression in cancer the expression of the final protein. Factors such as mRNA

Volume 1 Issue 1 (2022) 7 https://doi.org/10.36922/td.v1i1.59