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Tumor Discovery A bioinformatics analysis of PD-1 in cancers

Figure 4. Prognostic value of PD-1 mRNA expression in lung cancer patients. HR, hazard ratio.

degradation, protein degradation, and modification and patients with gastric cancer, even after stratification by
folding factors may cause inconsistency in mRNA abundance Her2 positivity. Same result was obtained for male patients
and protein expression level. with T2, intestinal-type cancer that received 5-FU-based

Multiple studies have shown that PD-1 is localized in chemotherapy. The expression of PD-1 is related to the
the interstitial lymphocytes in gastric cancer tissues, and expression of PD-L1 and forkhead box P3, and to the
[4]
its expression was higher than in normal tissues, but it has poor prognosis of gastric cancer . PD-1 and lymphocyte-
no correlation with the clinicopathological characteristics activation gene 3 expression on CD4+ and CD8+ T cells in
of gastric cancer patients [28-30] . PD-1 expression is higher gastric cancer patients was upregulated, and might be related
in the gastric cancer tissue and is associated with TNM to cell-mediated immune impairment in gastric cancer.
staging . Our study showed that higher PD-1 expression Therefore, the PD-1/PD-L1 pathway might be a new target
[31]
was negatively associated with the OS and PPS rates of all for gastric cancer . PD-1 expression in NSCLC tissues was
[32]
Volume 1 Issue 1 (2022) 8 https://doi.org/10.36922/td.v1i1.59