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Tumor Discovery Targeted drug delivery systems for the treatment of tumors

concept with significant potential for the precise recognition Ethics approval and consent to participate
of molecular addresses, bioimaging, and disease tracking
at the tumor sites. These exclusive attributes have enabled Not applicable.
researchers to develop novel approaches, including Consent for publication
monotherapy and combination therapy (through ligand
conjugation), aimed at improving tumor management. Not applicable.
Polymeric-targeted approaches exhibit the efficiency to Availability of data
specifically enter the tumor vasculature without affecting
neighbor cells and tissues. While these nanosystems offer Not applicable.
promising alternatives for tumor management, they are not
without challenges. These challenges include addressing References
the altered tumor microenvironment, improving uptake 1. Rankin EB, Giaccia AJ, 2016, Hypoxic control of metastasis.
and internalization, overcoming the narrow therapeutic Science, 352: 175–180.
window for therapeutics, and navigating the regulatory https://doi.org/10.1126/science.aaf4405
processes required for approval. Moreover, achieving a
vehicle with an extended biological half-life and enhanced 2. Abolhassani H, Wang Y, Hammarström L, et al., 2021,
Hallmarks of cancers: Primary antibody deficiency Versus
targeting efficiency is crucial for site-specific actions. other inborn errors of immunity. Front Immunol, 12: 720025.
Current targeted approaches primarily emphasize safety and
efficiency at the cancerous site. However, they also require https://doi.org/10.3389/fimmu.2021.720025
careful consideration of potential long-term side effects, 3. Mi Y, Mu L, Huang K, et al., 2020, Hypoxic colorectal cancer
the determination of optimal dosage strength, and the cells promote metastasis of normoxic cancer cells depending
establishment of suitable conditions. Recent advancements on IL-8/p65 signaling pathway. Cell Death Dis, 11(7): 610.
have introduced precise treatment methods, such as siRNA https://doi.org/10.1038/s41419-020-02797-z
delivery, stem cell therapy, immune-based treatments, gene 4. Date AA, Hanes J, Ensign LM, 2016, Nanoparticles for oral
therapies, and ablation therapies. These approaches hold delivery: Design, evaluation and state-of-the-art. J Control
promise as alternatives to surgical procedures. Furthermore, Release, 240: 504–526.
newly introduced fields such as pathomics and radiomics
are highly favored for collecting extensive clinical data and https://doi.org/10.1016/j.jconrel.2016.06.016
designing novel strategies to predict well-defined responses 5. Wang AZ, Langer R, Farokhzad OC, 2012, Nanoparticle
and advancements in cancer management. delivery of cancer drugs. Annu Rev Med, 63: 185–198.
https://doi.org/10.1146/annurev-med-040210-162544
Acknowledgments
6. Gustafson HH, Holt-Casper D, Grainger DW, et al., 2015,
The authors sincerely acknowledge the School of Nanoparticle uptake: The phagocyte problem. Nano Today,
Pharmaceutical Sciences, Chhatrapati Shahu Ji Maharaj 10: 487–510.
University, Kanpur, for providing all working facilities that https://doi.org/10.1016/j.nantod.2015.06.006
contributed to the completion of this review article. Our
thanks are also extended to the Faculty of Pharmacy, Uttar 7. Andreone BJ, Chow BW, Tata A, et al., 2017, Blood-brain
Pradesh University of Medical Sciences, Saifai, Etawah, for barrier permeability is regulated by lipid transport-
dependent suppression of caveolae-mediated transcytosis.
their valuable assistance in collecting the data presented in Neuron, 94: 581–594.e5.
this manuscript.
https://doi.org/10.1016/j.neuron.2017.03.043
Funding 8. Sanchez-Covarrubias L, Slosky LM, Thompson BJ,
None. et al., 2014, Transporters at CNS barrier sites: Obstacles
or opportunities for drug delivery. Curr Pharm Des, 20: 1
Conflict of interest 422–1449.
https://doi.org/10.2174/13816128113199990463
The authors declare no conflict of interest.
9. Wang Y, Cai R, Chen C, 2019, The nano-bio interactions
Author contributions of nanomedicines: Understanding the biochemical driving
forces and redox reactions. Acc Chem Res, 52(6): 1507–1518.
Conceptualization: Kamla Pathak
Writing – original draft: Shashi Kiran Misra https://doi.org/10.1021/acs.accounts.9b00126
Writing – review and editing: Kamla Pathak 10. Sun B, Sun YY, Li XP, et al., 2019, Particle and bacteria

Volume 2 Issue 3 (2023) 22 https://doi.org/10.36922/td.1356