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Tumor Discovery Targeted drug delivery systems for the treatment of tumors

Table 9. Inorganic nanocarriers utilized in tumor management
Type of nanocarrier Inorganic compound Research highlights Applications References
Inorganic Superparamagnetic iron oxide Powerful noninvasive tool for Magnetic resonance imaging [152]
nanocarriers oxide bioimaging in chemotherapy
Glutathione-induced (i) Controlled nanomolar release of Monitoring and controlling [153]
6-mercaptopurine and anticancer drugs at target site Raman spectroscopic tool for
6-thioguanine-gold nanoparticles (ii) Effective live cell imaging technique tumor
siRNA/iron oxide composite (i) Coating of polyethyleneimine MCF-7/ADR breast cancer [154]
prevented the degradation of
composite
(ii) Reduced the expression of
P-glycoprotein through siRNA
transfection
Monodisperse gold-loaded iron Synergized enhancement of T1 and Liver tumor diagnosis [155]
oxide (GdIO) T2 contrast agents
Doxorubicin-embedded polymeric (i) Required a smaller dose of Chemophotothermal therapy [156]
gold nanoparticles doxorubicin
(ii) Greatly reduced tumor rate/growth
(iii) Provided high therapeutic
efficacy and less toxicity
Superparamagnetic iron oxide (i) Controlled clustering structure Mesenchymal stem cell [157]
(ii) Internalized within (MSC) tracking and magnetic
mesenchymal stem cells (MSCs) resonance imaging
Daunorubicin and (i) Increased tumor temperature Reversal of multiple drug [158]
5-bromotetrandrine-loaded iron (ii) Reduced p-gp and BCL-2 expression resistance (MDR) in
oxide nanoparticles (iii) Increased caspase-3 and Bax leukemia
expression
Quantum dots (QD) Beta-cyclodextrin functionalized (i) Down-regulation of P-gp and Real-time tracking and [159]
(CdSe/ZnSe) QDs for co-delivery mdr1 mRNA chemotherapeutic agent
of doxorubicin and siRNA (ii) Enabled tracking through laser
confocal microscopy
Dual receptor (EGRF and integrin (i) Enhanced gene silencing Non-viral gene carrier for [160]
ανβ3) targeted QD/AS-ODN/ efficiency tumor management
GE11-c(RGDfK) (ii) Augmented cellular uptake
Manganese doped-zinc selenide (i) High gene transfection efficiency Delivery of siRNA to [161]
quantum dots (ii) Biocompatible, and stable pancreatic cancer
Carbon-based Paclitaxel-C6 ceramide (i) No toxicity in cell viability MDR-pancreatic cancer [162]
nanocarriers (ii) Improved aqueous solubility of
paclitaxel
(iii) Required 100 times less drug
Single-walled and multiwalled (i) Enhanced tissue penetration Imaging probes [163]
carbon nanotubes (SWNTs and (ii) Provided spatial resolution (photoacoustic imaging)
MWNTs) (iii) Served as T2 contrast agent
PEGylated MWNTs (i) Promped drug efflux in MDR cells Drug conjugate carrier for [164]
(ii) Stimulated ATPase activity of p-gp chemotherapy
Mesoporous silica Trimethylammonium mesoporous (i) High-efficient optical imaging In vivo optical imaging [165]
silica of organs
(ii) Stable composite within a wide
range of pH
Doxorubicin-loaded hollow (i) Displayed pore size-dependent MDR reversion [166]
mesoporous silica antitumor activity
(ii) Enhanced intracellular action
with high MDR reversal effect
TPGS (D-tocopheryl poly ethylene (i) Internalization through clathrin- Reversal MDR in tumor [167]
glycol 1000 succinate) modified mediated endocytosis management
DOX- MSN (ii) 10-fold higher killing potency
Magnetic silica nanospheres Efficient cellular uptake Magnetic resonance imaging [168]

Volume 2 Issue 3 (2023) 20 https://doi.org/10.36922/td.1356