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Tumor Discovery Missense mutations in CXCR1: Impact on stability and function
Score −7.852 −6.114 −5.374 −4.576 −4.449 −5.697 −6.065 −3.302 −3.604 −4.447 −7.124 −7.135 −8.016 −12.088 −9.933 −3.612 −3.515 −4.345 −5.763 −4.461 −2.684 −7.819 −5.796 −3.479 −6.491 −5.963 −4.307 −4.734 −4.834 −9.54 (Cont’d...)
PROVEAN Prediction Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful
Score 0.77 0.9 0.71 0.9 0.9 0.69 0.9 0.56 0.54 0.58 0.91 0.91 0.91 0.91 0.91 0.91 0.69 0.81 0.91 0.91 0.6 0.85 0.91 0.84 0.91 0.91 0.89 0.69 0.74 0.9
PMut
Prediction Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful
Score 0.843 0.764 0.802 0.74 0.886 0.835 0.838 0.568 0.64 0.577 0.847 0.852 0.89 0.905 0.947 0.787 0.634 0.754 0.739 0.715 0.6 0.728 0.725 0.65 0.834 0.779 0.781 0.627 0.773 0.85
Meta‑SNP
Prediction Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful
Computational tool SNAP Score Prediction 0.75 Harmful 0.665 Harmful 0.72 Harmful 0.615 Harmful 0.85 Harmful 0.76 Harmful 0.76 Harmful 0.58 Harmful 0.76 Harmful 0.64 Harmful 0.75 Harmful 0.75 Harmful 0.83 Harmful 0.885 Harmful 0.87 Harmful 0.74 Harmful 0.75 Harmful 0.725 Harmful 0.74 Harmful 0.665 Harmful 0.635 Harmful 0.73 Harmful 0.755 Harmful 0.68 Harmful 0.775 Harmful 0.78 Harmful 0.81 Harmful 0
Score 0.02 0 0.04 0.01 0 0 0 0.04 0.03 0.03 0 0 0 0 0 0.01 0.02 0.03 0.01 0 0.02 0.02 0 0.05 0.01 0 0 0.05 0.04 0.04
SIFT
Table 1. Predicted deleterious CXCR1 mutations using computational tools
Prediction Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful
Score 0.916 0.852 0.873 0.726 0.807 0.862 0.874 0.805 0.814 0.827 0.874 0.838 0.894 0.958 0.962 0.892 0.797 0.865 0.879 0.671 0.773 0.934 0.919 0.859 0.898 0.947 0.876 0.61 0.866 0.838
PhD‑SNP Prediction Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful
Score 0.824 0.599 0.801 0.805 0.976 0.84 0.802 0.692 0.702 0.611 0.99 0.992 0.996 0.994 0.999 0.973 0.584 0.552 0.965 0.898 0.746 0.973 0.923 0.861 0.996 0.99 0.992 0.909 0.929 0.981
PANTHER Prediction Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful Harmful
Mutants Y46C V49G L51P L52Q N57D L59P L78P A82V D85N T91I P93S P93T P93H W103R C110W K111E Y122H G124D L127P I131T S132N D134V D134G D134E R135C R135L R135H I139T V140F C157F
Serial number 38 39 42 43 45 47 70 73 75 79 81 82 83 89 99 100 106 107 109 111 113 115 116 117 118 119 120 122 123 136
Volume 3 Issue 1 (2024) 6 https://doi.org/10.36922/td.2512
