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Tumor Discovery Missense mutations in CXCR1: Impact on stability and function

Table 2. (Continued)
Serial number Computational server
SDM mCSM DUET
ΔΔG Prediction of protein stability ΔΔG Prediction of protein stability ΔΔG Prediction of protein stability
44 −0.67 Decrease −1.492 Damaging −1.302 Damaging
45 −0.62 Decrease −2.418 Highly damaging −2.346 Damaging
46 0.43 Enhance −0.838 Damaging −0.466 Damaging
47 −2.23 Decrease −0.799 Damaging −1.093 Damaging
48 −0.15 Decrease −1.34 Damaging −0.823 Damaging
49 0.11 Enhance −0.995 Damaging −0.382 Damaging
50 −2.23 Decrease −0.793 Damaging −1.086 Damaging
51 −0.2 Decrease 0.141 Stabilizing 0.532 Stabilizing
52 −1.5 Decrease −1.928 Damaging −2.145 Damaging
53 −0.35 Decrease −1.305 Damaging −1.083 Damaging
54 −0.91 Decrease −0.095 Damaging 0.13 Stabilizing
55 −1.51 Decrease −0.661 Damaging −0.629 Damaging
56 0.22 Enhance −0.199 Damaging 0.255 Stabilizing
57 −1.21 Decrease −0.267 Damaging −0.138 Damaging
58 −0.3 Decrease −0.47 Damaging −0.246 Damaging
59 −0.4 Decrease −0.633 Damaging −0.48 Damaging
60 −0.33 Decrease −0.293 Damaging −0.291 Damaging
61 0.09 Enhance −0.657 Damaging −0.537 Damaging
62 −0.59 Decrease −0.984 Damaging −0.909 Damaging
63 0.35 Enhance −0.726 Damaging −0.256 Damaging
64 −0.01 Decrease −1.113 Damaging −0.965 Damaging
65 −0.17 Decrease −0.79 Damaging −0.529 Damaging
66 −0.97 Decrease −1.319 Damaging −1.476 Damaging
67 −0.2 Decrease −0.734 Damaging −0.402 Damaging
68 0.11 Enhance −1.439 Damaging −0.979 Damaging
69 −1.35 Decrease −2.371 Highly damaging −2.214 Damaging
70 −2.75 Decrease −0.963 Damaging −1.327 Damaging
71 −0.52 Decrease −0.638 Damaging −0.101 Damaging
72 0.12 Enhance −1.215 Damaging −0.799 Damaging
73 −0.85 Decrease −0.668 Damaging −0.546 Damaging
74 −3.32 Decrease −2.982 Highly damaging −3.32 Damaging
75 0.57 Enhance −1.063 Damaging −0.659 Damaging
76 −0.37 Decrease −0.994 Damaging −0.708 Damaging
77 −1.41 Decrease −1.807 Damaging −1.933 Damaging
78 −2.61 Decrease −1.29 Damaging −1.518 Damaging
80 −1.48 Decrease −1.249 Damaging −1.528 Damaging
81 1.62 Enhance −1.559 Damaging −1.017 Damaging
82 0.34 Enhance −1.298 Damaging −0.848 Damaging
83 1.06 Enhance −1.306 Damaging −0.776 Damaging
84 −2.83 Decrease −2.726 Highly damaging −2.636 Damaging
(Cont’d...)

Volume 3 Issue 1 (2024) 9 https://doi.org/10.36922/td.2512