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Tumor Discovery Missense mutations in CXCR1: Impact on stability and function

Table 2. (Continued)
Serial number Computational server
SDM mCSM DUET
ΔΔG Prediction of protein stability ΔΔG Prediction of protein stability ΔΔG Prediction of protein stability
169 −1.16 Decrease −0.462 Damaging −0.005 Damaging
170 −2 Decrease −1.04 Damaging −1.504 Damaging
171 0.54 Enhance −0.842 Damaging −0.13 Damaging
172 −0.72 Decrease −1.493 Damaging −1.341 Damaging
173 0.84 Enhance −1.165 Damaging −0.552 Damaging
174 −2.59 Decrease −2.779 Highly damaging −3.094 Damaging
175 −0.55 Decrease −0.853 Damaging −0.801 Damaging
176 0.37 Enhance −0.144 Damaging 0.025 Stabilizing
177 −0.8 Decrease −1.71 Damaging −1.572 Damaging
178 −1.5 Decrease −1.578 Damaging −1.435 Damaging
179 −2.11 Decrease −1.044 Damaging −1.096 Damaging
180 −0.35 Decrease −0.933 Damaging −0.892 Damaging
181 0.21 Enhance −0.998 Damaging −0.712 Damaging
182 0.1 Enhance −1.409 Damaging −1.197 Damaging
183 −2.05 Decrease −0.47 Damaging −0.695 Damaging
184 −2.67 Decrease −0.991 Damaging −1.342 Damaging
185 0.16 Enhance −0.173 Damaging 0.098 Stabilizing
186 3.38 Enhance −0.426 Damaging 0.61 Stabilizing
187 0.64 Enhance −0.823 Damaging −0.527 Damaging
188 0.35 Enhance −0.51 Damaging −0.027 Damaging
189 0.18 Enhance −0.833 Damaging −0.274 Damaging
190 −1.5 Decrease −1.457 Damaging −1.465 Damaging
191 1.07 Enhance −0.772 Damaging −0.327 Damaging
192 1.64 Enhance −0.581 Damaging 0.173 Stabilizing
193 1.36 Enhance −1.094 Damaging −0.279 Damaging
194 −1.22 Decrease −0.326 Damaging −0.524 Damaging
195 −1.82 Decrease −0.345 Damaging −0.662 Damaging
196 −0.7 Decrease −1.456 Damaging −1.455 Damaging
197 −0.74 Decrease −0.821 Damaging −0.811 Damaging
198 −0.82 Decrease −0.238 Damaging −0.172 Damaging
199 0.64 Enhance −0.865 Damaging −0.547 Damaging
200 −0.67 Decrease −0.378 Damaging −0.295 Damaging
201 −0.35 Decrease −0.688 Damaging −0.568 Damaging
203 0.6 Enhance −0.361 Damaging 0.179 Stabilizing
204 0.54 Enhance 0.267 Damaging 0.276 Stabilizing
205 −0.19 Decrease 0.832 Stabilizing 0.982 Stabilizing
206 0.72 Enhance −0.394 Damaging −0.021 Damaging
208 −0.48 Decrease −0.79 Damaging −0.732 Damaging
209 0.79 Enhance −0.491 Damaging −0.298 Damaging
210 −1.06 Decrease −0.168 Damaging −0.363 Damaging
211 −1.53 Decrease −1.021 Damaging −1.229 Damaging
(Cont’d...)

Volume 3 Issue 1 (2024) 12 https://doi.org/10.36922/td.2512