Page 78 - TD-3-1

Tumor Discovery Missense mutations in CXCR1: Impact on stability and function

Table 2. (Continued)
Serial number Computational server
SDM mCSM DUET
ΔΔG Prediction of protein stability ΔΔG Prediction of protein stability ΔΔG Prediction of protein stability
255 −2.23 Decrease −1.524 Damaging −1.886 Damaging
256 −2.51 Decrease −1.068 Damaging −1.314 Damaging
257 −1.48 Decrease −1.602 Damaging −1.8 Damaging
258 −1.2 Decrease −1.282 Damaging −1.375 Damaging
259 0.62 Enhance −2.554 Highly damaging −2.103 Damaging
260 −1.37 Decrease −2.77 Highly damaging −2.94 Damaging
261 −2.75 Decrease −0.921 Damaging −1.194 Damaging
262 −0.6 Decrease −1.188 Damaging −1.162 Damaging
263 −1.8 Decrease −2.268 Highly damaging −2.523 Damaging
264 −0.25 Decrease −1.212 Damaging −1.028 Damaging
265 0.08 Enhance −0.499 Damaging −0.179 Damaging
266 −1.1 Decrease −1.912 Damaging −1.991 Damaging
267 −0.77 Decrease −1.415 Damaging −1.386 Damaging
269 0.39 Enhance −0.398 Damaging −0.124 Damaging
270 1.73 Enhance −1.155 Damaging −0.344 Damaging
271 −0.37 Decrease −0.609 Damaging −0.29 Damaging
272 −0.98 Decrease −1.443 Damaging −1.302 Damaging
273 −2.78 Decrease −1.231 Damaging −1.766 Damaging
274 −1.59 Decrease −1.302 Damaging −1.54 Damaging
275 −1.29 Decrease 0.235 Stabilizing 0.407 Stabilizing
276 −0.5 Decrease −0.018 Damaging 0.31 Stabilizing
277 −0.85 Decrease −0.131 Damaging −0.098 Damaging
278 −0.3 Decrease −0.162 Damaging −0.04 Damaging
279 −0.46 Decrease 0.152 Stabilizing 0.096 Stabilizing
280 −0.31 Decrease −0.642 Damaging −0.45 Damaging
281 0.22 Enhance −0.481 Damaging −0.154 Damaging
283 −0.7 Decrease −0.927 Damaging −0.935 Damaging
284 −0.52 Decrease 0.043 Stabilizing 0.025 Stabilizing
285 −0.13 Decrease −1.119 Damaging −0.996 Damaging
286 −0.8 Decrease −0.131 Damaging −0.21 Damaging
287 −1.24 Decrease 0.335 Stabilizing 0.197 Stabilizing
288 −0.45 Decrease −0.863 Damaging −0.798 Damaging
289 −0.5 Decrease −0.369 Damaging −0.14 Damaging
290 −1.19 Decrease −0.442 Damaging −0.65 Damaging
291 0.86 Enhance −1.18 Damaging −0.745 Damaging
292 0.52 Enhance −1.572 Damaging −1.227 Damaging
293 0.58 Enhance −0.397 Damaging −0.006 Damaging
294 −0.5 Decrease −1.064 Damaging −1.231 Damaging
295 −0.44 Decrease −1.581 Damaging −1.556 Damaging
296 −0.71 Decrease −1.476 Damaging −1.407 Damaging
297 0.59 Enhance −1.611 Damaging −1.089 Damaging
298 −1.7 Decrease −2.091 Highly damaging −2.354 Damaging
299 −0.51 Decrease −1.611 Damaging −1.737 Damaging
Abbreviation: ΔΔG: Difference in free energy between the mutant and wild−type proteins.

Volume 3 Issue 1 (2024) 14 https://doi.org/10.36922/td.2512