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Tumor Discovery Missense mutations in CXCR1: Impact on stability and function

Table 2. (Continued)
Serial number Computational server
SDM mCSM DUET
ΔΔG Prediction of protein stability ΔΔG Prediction of protein stability ΔΔG Prediction of protein stability
212 −0.28 Decrease −0.405 Damaging −0.325 Damaging
213 −2.99 Decrease −2.176 Highly damaging −2.148 Damaging
214 −0.25 Decrease −0.363 Damaging 0.047 Stabilizing
215 −0.86 Decrease −1.782 Damaging −1.638 Damaging
216 −0.3 Decrease −1.239 Damaging −1.197 Damaging
217 −0.84 Decrease 0.386 Stabilizing 0.671 Stabilizing
218 −0.18 Decrease 0.15 Stabilizing 0.529 Stabilizing
219 −0.53 Decrease −0.361 Damaging −0.323 Damaging
220 0.49 Enhance −2.066 Highly damaging −1.769 Damaging
221 −1.53 Decrease −1.463 Damaging −1.42 Damaging
222 0.03 Enhance −1.458 Damaging −0.939 Damaging
223 0.01 Enhance −1.507 Damaging −1.291 Damaging
224 −0.09 Decrease −1.052 Damaging −0.497 Damaging
225 −0.99 Decrease −0.705 Damaging −0.083 Damaging
226 0.13 Enhance −1.026 Damaging −0.7 Damaging
227 −0.43 Decrease −0.757 Damaging −0.397 Damaging
228 1.51 Enhance −0.009 Damaging 0.775 Stabilizing
229 −0.44 Decrease −0.52 Damaging −0.301 Damaging
230 −0.45 Decrease −0.405 Damaging −0.379 Damaging
231 0.04 Enhance −1.163 Damaging −0.919 Damaging
232 −0.61 Decrease −0.787 Damaging −0.67 Damaging
233 0.09 Enhance −0.482 Damaging −0.088 Damaging
234 −0.15 Decrease −0.328 Damaging 0.074 Stabilizing
235 −1.01 Decrease 0.263 Stabilizing 0.474 Stabilizing
236 −2.54 Decrease −0.193 Damaging −0.826 Damaging
237 −1.1 Decrease −1.393 Damaging −1.484 Damaging
238 −0.87 Decrease −0.582 Damaging −0.543 Damaging
239 −0.65 Decrease −0.863 Damaging −0.775 Damaging
240 0.08 Enhance −0.095 Damaging 0.19 Stabilizing
241 −0.46 Decrease −1.561 Damaging −1.499 Damaging
242 −0.3 Decrease −1.574 Damaging −1.512 Damaging
243 −0.35 Decrease −1.331 Damaging −1.096 Damaging
244 0.72 Enhance −0.648 Damaging −0.031 Damaging
245 0.18 Enhance −1.09 Damaging −0.83 Damaging
246 0.49 Enhance −0.546 Damaging −0.449 Damaging
248 0.04 Enhance −0.272 Damaging −0.104 Damaging
249 −2.05 Decrease −0.901 Damaging −0.916 Damaging
251 −1.56 Decrease −0.543 Damaging −0.551 Damaging
252 2.06 Enhance −0.959 Damaging −0.022 Damaging
253 −1.01 Decrease −0.282 Damaging −0.044 Damaging
254 −2.23 Decrease −2.109 Highly damaging −2.322 Damaging
(Cont’d...)

Volume 3 Issue 1 (2024) 13 https://doi.org/10.36922/td.2512