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Tumor Discovery Missense mutations in CXCR1: Impact on stability and function

Table 2. Predicted CXCR1 mutations that decrease or damage protein stability using computational servers
Serial number Computational server
SDM mCSM DUET
ΔΔG Prediction of protein stability ΔΔG Prediction of protein stability ΔΔG Prediction of protein stability
1 0 Enhance −0.8 Damaging −0.49 Damaging
2 0 Enhance −0.989 Damaging −0.691 Damaging
4 0 Enhance −0.623 Damaging −0.253 Damaging
5 0 Enhance −0.8 Damaging −0.49 Damaging
6 −1.29 Decrease −0.88 Damaging −0.959 Damaging
7 0.02 Enhance −0.126 Damaging 0.101 Stabilizing
8 −0.05 Decrease −1.091 Damaging −0.676 Damaging
9 −0.42 Decrease −2.522 Highly damaging −2.139 Damaging
10 −0.59 Decrease −2.751 Highly damaging −2.931 Damaging
11 −0.8 Decrease −3.373 Highly damaging −3.693 Damaging
12 −0.46 Decrease −0.337 Damaging −0.444 Damaging
13 −0.25 Decrease −0.635 Damaging −0.508 Damaging
14 −0.18 Decrease −0.387 Damaging −0.031 Damaging
15 0.1 Enhance −0.375 Damaging −0.062 Damaging
16 0.78 Enhance −0.28 Damaging 0.24 Stabilizing
17 −0.18 Decrease −0.543 Damaging −0.292 Damaging
18 −0.43 Decrease −0.295 Damaging −0.011 Damaging
19 −0.11 Decrease −0.573 Damaging −0.274 Damaging
20 −0.11 Decrease 0.093 Stabilizing 0.172 Stabilizing
21 3.78 Enhance −0.42 Damaging 0.437 Stabilizing
22 1.18 Enhance −0.265 Damaging 0.111 Stabilizing
24 0.78 Enhance −0.297 Damaging 0.296 Stabilizing
25 −0.29 Decrease −0.623 Damaging −0.456 Damaging
26 0.67 Enhance −0.531 Damaging −0.09 Damaging
27 0.25 Enhance −0.6 Damaging −0.151 Damaging
28 −0.5 Decrease −0.125 Damaging 0.139 Stabilizing
29 0.34 Enhance −0.048 Damaging 0.468 Stabilizing
30 −0.98 Decrease −0.491 Damaging −0.407 Damaging
31 −0.63 Decrease −0.814 Damaging −0.846 Damaging
32 0.36 Enhance −0.299 Damaging 0.192 Stabilizing
34 0.23 Enhance −0.398 Damaging 0.045 Stabilizing
35 −0.65 Decrease −0.231 Damaging 0.174 Stabilizing
36 0.09 Enhance −0.598 Damaging −0.221 Damaging
37 −2.05 Decrease −1.013 Damaging −1.122 Damaging
38 −1.01 Decrease −1.571 Damaging −1.411 Damaging
39 −2.5 Decrease −2.547 Highly damaging −2.932 Damaging
40 0.64 Enhance −1.12 Damaging −0.806 Damaging
41 0.04 Enhance −1.266 Damaging −1.102 Damaging
42 −2.23 Decrease −0.564 Damaging −0.569 Damaging
43 −2.23 Decrease −1.29 Damaging −1.158 Damaging
(Cont’d...)

Volume 3 Issue 1 (2024) 8 https://doi.org/10.36922/td.2512