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Tumor Discovery Missense mutations in CXCR1: Impact on stability and function

Table 2. (Continued)
Serial number Computational server
SDM mCSM DUET
ΔΔG Prediction of protein stability ΔΔG Prediction of protein stability ΔΔG Prediction of protein stability
85 −1.49 Decrease −1.472 Damaging −1.575 Damaging
86 −1.53 Decrease −1.293 Damaging −1.237 Damaging
87 0.65 Enhance −0.161 Damaging 0.297 Stabilizing
88 −2.65 Decrease −1.377 Damaging −1.674 Damaging
89 −0.4 Decrease −1.656 Damaging −1.308 Damaging
90 −0.22 Decrease −1.243 Damaging −1.164 Damaging
91 −0.03 Decrease −0.151 Damaging 0.239 Stabilizing
92 −1.33 Decrease −0.923 Damaging −0.83 Damaging
93 −0.65 Decrease −1.619 Damaging −1.655 Damaging
94 0.37 Enhance −1.002 Damaging −0.604 Damaging
95 −1.47 Decrease −0.408 Damaging −0.546 Damaging
96 0.64 Enhance −0.62 Damaging −0.322 Damaging
97 0.47 Enhance −0.349 Damaging 0.008 Stabilizing
98 0.64 Enhance −0.62 Damaging −0.322 Damaging
99 −2.1 Decrease −1.016 Damaging −1.246 Damaging
100 0.09 Enhance −1.65 Damaging −1.233 Damaging
101 0.07 Enhance −1.903 Damaging −1.582 Damaging
102 0.18 Enhance −1.353 Damaging −1.029 Damaging
103 0.16 Enhance −0.107 Damaging 0.101 Stabilizing
104 −1.65 Decrease −0.904 Damaging −1.041 Damaging
105 −0.53 Decrease −1.465 Damaging −1.453 Damaging
106 0.12 Enhance −0.56 Damaging −0.459 Damaging
107 −1.31 Decrease −1.67 Damaging −1.548 Damaging
108 0.78 Enhance −1.844 Damaging −1.726 Damaging
109 −2.55 Decrease −1.164 Damaging −1.541 Damaging
110 −4.41 Decrease −1.686 Damaging −2.378 Damaging
111 −2.05 Decrease −1.481 Damaging −1.619 Damaging
112 −3.12 Decrease −2.55 Highly damaging −2.883 Damaging
113 −1.12 Decrease −0.883 Damaging −0.605 Damaging
114 0.06 Enhance −1.291 Damaging −1.084 Damaging
115 0.16 Enhance −0.467 Damaging −0.21 Damaging
117 −0.32 Decrease −1.154 Damaging −1.048 Damaging
118 1.25 Enhance −0.593 Damaging 0.048 Stabilizing
119 −0.74 Decrease −0.781 Damaging −0.681 Damaging
120 0.3 Enhance −0.047 Damaging 0.352 Stabilizing
121 −0.06 Decrease −1.476 Damaging −1.263 Damaging
122 −2.05 Decrease −1.446 Damaging −1.582 Damaging
123 −1.06 Decrease −1.247 Damaging −1.171 Damaging
124 −0.09 Decrease −1.191 Damaging −1.071 Damaging
125 −0.35 Decrease −0.029 Damaging −0.118 Damaging
126 −0.38 Decrease −0.181 Damaging −0.253 Damaging
(Cont’d...)

Volume 3 Issue 1 (2024) 10 https://doi.org/10.36922/td.2512