Page 71 - TD-3-1
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Tumor Discovery                                      Missense mutations in CXCR1: Impact on stability and function





                      Score  −11.781  −11.797  −4.409  −6.798  −8.641  −7.963  −6.653  −9.694  −7.669  −4.677  −6.676  −3.868  −7.691  −6.313  −8.438  −7.503  −5.543  −7.503  −5.627  −4.288  −6.834  −4.91  −5.456
                    PROVEAN   Prediction  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful






                      Score  0.9  0.9  0.9  0.86  0.87  0.9  0.9  0.9  0.91  0.9  0.9  0.84  0.9  0.91  0.85  0.91  0.91  0.91  0.72  0.75  0.82  0.9  0.69


                    PMut
                      Prediction  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful




                      Score  0.824  0.831  0.778  0.689  0.679  0.902  0.844  0.853  0.852  0.806  0.75  0.658  0.908  0.869  0.849  0.938  0.773  0.876  0.861  0.722  0.825  0.701  0.828
                    Meta‑SNP  Prediction  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful





                 Computational tool  SNAP  Score  Prediction  0.78  Harmful  0.8  Harmful  0.715  Harmful  0.71  Harmful  0.63  Harmful  0.88  Harmful  0.73  Harmful  0.665  Harmful  0.63  Harmful  0.67  Harmful  0.645  Harmful  0.655  Harmful  0.76  Harmful  0.825  Harmful  0.74  Harmful  0.76  Harmful  0.675  Harmful  0.69  Harmful  0.595  Harmful  0.565  Harmful  0.73  Harmful  0.555  Harmful  0.755  Harmful








                      Score  0.03  0.01  0  0.01  0.04  0.02  0.01  0.01  0.02  0.01  0  0.01  0  0  0.02  0  0  0  0.03  0.03  0  0.04  0.01

                    SIFT
                      Prediction  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful




                      Score  0.857  0.912  0.807  0.819  0.891  0.869  0.901  0.903  0.888  0.846  0.865  0.819  0.853  0.877  0.961  0.873  0.845  0.914  0.909  0.862  0.927  0.611  0.889
                    PhD‑SNP   Prediction  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful





                      Score  0.997  0.998  0.88  0.776  0.822  0.993  0.981  0.994  0.998  0.683  0.82  0.627  1  0.843  0.976  1  0.776  0.998  0.998  0.566  0.795  0.855  0.773
                    PANTHER  Prediction  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful  Harmful






             Table 1. (Continued)  Mutants  Serial   number  W161L  139  W161C  140  S164F  142  P170T  146  P170L  147  C187Y  160  F211V  183  P214L  185  Y222C  189  T225P  193  I244N  214  I244F  215  P257S  219  L293P  254  C299F  257  P302S  258  I304N  259  F312S  262  F312I  263  R313H  265  R313C  267  I319N  272  L320P  273











            Volume 3 Issue 1 (2024)                         7                          https://doi.org/10.36922/td.2512
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