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Tumor Discovery Missense mutations in CXCR1: Impact on stability and function

Table 2. (Continued)
Serial number Computational server
SDM mCSM DUET
ΔΔG Prediction of protein stability ΔΔG Prediction of protein stability ΔΔG Prediction of protein stability
127 0.19 Enhance −1.058 Damaging −0.982 Damaging
128 −0.33 Decrease −0.244 Damaging −0.312 Damaging
129 0.42 Enhance −0.229 Damaging 0.08 Stabilizing
130 0.27 Enhance −0.333 Damaging −0.096 Damaging
131 −0.19 Decrease −0.034 Damaging 0.08 Stabilizing
132 −1.02 Decrease −1.125 Damaging −1.246 Damaging
133 −0.71 Decrease −0.389 Damaging −0.304 Damaging
134 0.65 Enhance 1.207 Stabilizing 1.307 Stabilizing
135 −0.63 Decrease −1.173 Damaging −1.225 Damaging
136 −0.09 Decrease −1.133 Damaging −1.103 Damaging
137 −1.5 Decrease −1.281 Damaging −1.426 Damaging
138 −0.63 Decrease −0.974 Damaging −0.997 Damaging
139 0.16 Enhance −0.175 Damaging 0.345 Stabilizing
140 0.23 Enhance −1.909 Damaging −1.398 Damaging
141 0.08 Enhance −1.432 Damaging −1.007 Damaging
142 −2.23 Decrease −0.758 Damaging −0.987 Damaging
143 −0.2 Decrease −1.02 Damaging −0.766 Damaging
144 0.49 Enhance −1.088 Damaging −0.526 Damaging
145 0.11 Enhance −0.405 Damaging 0.211 Stabilizing
146 0.49 Enhance −1.618 Damaging −1.179 Damaging
147 0.83 Enhance −1.285 Damaging −0.702 Damaging
149 0.11 Enhance −1.069 Damaging −0.916 Damaging
150 −0.65 Decrease −2.752 Highly damaging −2.836 Damaging
151 −1.29 Decrease −1.693 Damaging −2.099 Damaging
152 0.19 Enhance −1.548 Damaging −1.28 Damaging
153 0.25 Enhance −2.782 Highly damaging −2.451 Damaging
154 0.1 Enhance −1.463 Damaging −1.226 Damaging
155 −1.43 Decrease −1.591 Damaging −1.665 Damaging
156 −0.62 Decrease 0.073 Stabilizing 0.073 Stabilizing
157 0.94 Enhance −0.824 Damaging −0.379 Damaging
158 0.74 Enhance −0.654 Damaging −0.285 Damaging
159 −1.13 Decrease −0.654 Damaging −1.941 Damaging
160 −1.09 Decrease −0.594 Damaging −0.426 Damaging
161 −0.87 Decrease −1.035 Damaging −1.078 Damaging
162 −0.13 Decrease −0.78 Damaging −0.518 Damaging
163 −1.04 Decrease −1.811 Damaging −1.633 Damaging
164 −0.48 Decrease −1.084 Damaging −0.889 Damaging
165 0.84 Enhance −0.634 Damaging −0.28 Damaging
166 0.5 Enhance −0.254 Damaging 0.074 Stabilizing
167 0.33 Enhance −0.455 Damaging −0.561 Damaging
168 −3.33 Decrease −1.864 Damaging −2.165 Damaging
(Cont’d...)

Volume 3 Issue 1 (2024) 11 https://doi.org/10.36922/td.2512