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Tumor Discovery Pyroptosis-related genes in breast cancer progression

A B C

D E

F
G

Figure 10. (A-C) Expression of prognostic genes in breast cancer (BC). In MDA-MB-231 cells and MDA-MB-468 cells, the expressions of APOBEC3D and
APOBEC3F were much higher than in BT549 and MCF7. Notably, the same antibody was used for detecting both proteins APOBEC3D and APOBEC3F
in western blotting. (D-G) In addition, the expressions of PXDNL and ARMH1 were significantly higher in BC cells.
Notes: P-values: ns = not significant; *P < 0.05; **P < 0.01; ***P < 0.001.

additional research is needed to address the remaining Conflict of interest
questions and confirm these findings.
The authors declare that the research was conducted in the
5. Conclusion absence of any commercial or financial relationships that
could be construed as a potential conflicts of interest.
We identified four high-risk genes – FIBCD1, CACNA1H,
HSPB8, and PXDNL – that are involved in BC pyroptosis. Author contributions
Notably, the expression of PXDNL was significantly Conceptualization: Shanshan Wang, Dashuang Yang,
elevated in BC cells in vitro, suggesting that PXDNL could Jiaqian Mo
serve as a new target for early diagnosis and prognosis in Formal analysis: Moxian Chen
BC. Investigation: Shanshan Wang, Dashuang Yang, Jiaqian Mo

Acknowledgments Methodology: Shanshan Wang, Dashuang Yang, Jiaqian Mo
Writing-original draft: Shanshan Wang, Dashuang Yang,
None. Jiaqian Mo
Writing-review & editing: Rongxin Zhang
Funding
This work was supported by the Administration of Ethics approval and consent to participate
Traditional Chinese Medicine of Guangdong Province All BC clinical data were downloaded from the TCGA
(No. 20221218). database. The data provided by the database are ethically

Volume 3 Issue 3 (2024) 14 doi: 10.36922/td.3469