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Tumor Discovery Pyroptosis-related genes in breast cancer progression
A
B
Figure 7. Functional analysis based on The Cancer Genome Atlas cohort’s differential genes between the two risk categories
Notes: The larger the bubble, the more genes were enriched, and the deeper the red, the more noticeable the distinctions; q value = corrected P-value).
motif chemokine ligand 16, especially for brain and lung suppressing the activation of ErbB-2/neu-mediated Src
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metastasis. Fifth, DEF6 is a GEF for RAC and CDC42 family kinases through its SH2 domain to inhibit non-
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that is highly expressed in B and T cells. However, in breast dependent growth and cell invasion. 21,22 As mentioned
tumors, DEF6 regulates the epithelial-to-mesenchymal earlier, DIRAS3, MMP7, DEF6, and MATK were down-
transformation and movement and the migration, regulated in BC, indicating that further research may be
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invasion, and production of MMPs. Finally, MATK has an required to discover how they mediated BC cells, and a
inhibiting effect on the regulation of T-cell proliferation. joint study of BC and immune pathways may be carried
In breast tumors, MATK inhibits this proliferation by out in the future.
Volume 3 Issue 3 (2024) 10 doi: 10.36922/td.3469
