Page 55 - TD-3-4
P. 55

Tumor Discovery                                                                PPAR agonist and cancer



               doi: 10.1016/j.crphar.2022.100110               37.  Tyagi S, Gupta P, Saini AS, Kaushal C, Sharma S. The
                                                                  peroxisome proliferator-activated receptor: A  family of
            26.  Rathaur P, Soni MN, Gelat B, Rawal R, Pandya HA, Johar K.
               Network pharmacology-based evaluation of natural   nuclear receptors role in various diseases.  J  Adv Pharm
               compounds with paclitaxel for the treatment of metastatic   Technol Res. 2011;2(4):236-240.
               breast cancer. Toxicol Appl Pharmacol. 2021;423:115576.     doi: 10.4103/2231-4040.90879
               doi: 10.1016/j.taap.2021.115576                 38.  Tan Y, Wang M, Yang K, Chi T, Liao Z, Wei P. PPAR-α
                                                                  modulators as current and potential cancer treatments.
            27.  Rodrigues R, Duarte D, Vale N. Drug repurposing in cancer
               therapy: Influence of patient’s genetic background in breast   Front Oncol. 2021;11:599995.
               cancer treatment. Int J Mol Sci. 2022;23(8):4280.     doi: 10.3389/fonc.2021.599995
               doi: 10.3390/ijms23084280                       39.  Chi T, Wang M, Wang X,  et al. PPAR-γ modulators as
                                                                  current and potential cancer treatments.  Front Oncol.
            28.  Jourdan JP, Bureau R, Rochais C, Dallemagne P. Drug
               repositioning: A  brief overview.  J  Pharm Pharmacol.   2021;11:737776.
               2020;72(9):1145-1151.                              doi: 10.3389/fonc.2021.737776
               doi: 10.1111/jphp.13273                         40.  Cheng HS, Tan WR, Low ZS, Marvalim C, Lee JYH, Tan NS.
                                                                  Exploration and development of PPAR modulators in health
            29.  Oprea TI, Mestres J. Drug repurposing: Far beyond new
               targets for old drugs. AAPS J. 2012;14(4):759-763.  and disease: An update of clinical evidence. Int J Mol Sci.
                                                                  2019;20(20):5055.
               doi: 10.1208/s12248-012-9390-1
                                                                  doi: 10.3390/ijms20205055
            30.  Patel B, Gelat B, Soni M, Rathaur P, Kaid Johar SR.   41.  Kim SY, Kim MS, Lee MK, et al. PPAR-γ induces growth
               Bioinformatics perspective of drug repurposing.  Curr   inhibition and apoptosis through upregulation of insulin-
               Bioinform. 2024;19(4):295-315.
                                                                  like growth factor-binding protein-3 in gastric cancer cells.
               doi: 10.2174/0115748936264692230921071504          Braz J Med Biol Res. 2015;48(3):226-233.
            31.  Kulkarni VS, Alagarsamy V, Solomon VR, Jose PA,      doi: 10.1590/1414-431X20144212
               Murugesan S. Drug repurposing: An effective tool in modern   42.  Skelhorne-Gross G, Nicol CJB. The key to unlocking the
               drug discovery. Russ J Bioorg Chem. 2023;49(2):157-166.
                                                                  chemotherapeutic potential of PPAR-γ ligands: Having the
               doi: 10.1134/S1068162023020139                     right combination. PPAR Res. 2012;2012:946943.
            32.  Botta  M,  Audano  M,  Sahebkar  A,  Sirtori  CR,  Mitro  N,      doi: 10.1155/2012/946943
               Ruscica M. PPAR agonists and metabolic syndrome: An   43.  Panigrahy D, Kaipainen A, Huang S, et al. PPARα agonist
               established role? Int J Mol Sci. 2018;19(4):1197.
                                                                  fenofibrate suppresses tumor growth through direct and
               doi: 10.3390/ijms19041197                          indirect angiogenesis  inhibition.  Proc Natl Acad Sci.
            33.  Mirza AZ, Althagafi II, Shamshad H. Role of PPAR receptor   2008;105(3):985-990.
               in different diseases and their ligands: Physiological      doi: 10.1073/pnas.0711281105
               importance and clinical implications.  Eur  J Med  Chem.   44.  Rigano D, Sirignano C, Taglialatela-Scafati O. The potential
               2019;166:502-513.
                                                                  of natural products for targeting PPARα. Acta Pharm Sinica
               doi: 10.1016/j.ejmech.2019.01.067                  B. 2017;7(4):427-438.
            34.  van Raalte DH, Li M, Pritchard PH, Wasan KM.      doi: 10.1016/j.apsb.2017.05.005
               Peroxisome proliferator-activated receptor (PPAR)-α:
               A pharmacological target with a promising future. Pharm   45.  Chiarelli F, Marzio DD. Peroxisome proliferator-activated
                                                                  receptor-γ agonists and diabetes: Current evidence and future
               Res. 2004;21:1531-1538.
                                                                  perspectives. Vasc Health Risk Manag. 2008;4(2):297-304.
               doi: 10.1023/b: pham.0000041444.06122.8d
                                                                  doi: 10.2147/vhrm.s993
            35.  Corrales P, Vidal-Puig A, Medina-Gómez G. PPARs and   46.  Ngoc LP, Man HY, Besselink H, Cam HD, Brouwer A, van
               metabolic  disorders  associated  with  challenged  adipose   der Burg B. Identification of PPAR-activating compounds in
               tissue plasticity. Int J Mol Sci. 2018;19(7):2124.
                                                                  herbal and edible plants and fungi from Vietnam. Ind Crops
               doi: 10.3390/ijms19072124                          Prod. 2019;129:195-200.
            36.  Gross B, Pawlak M, Lefebvre P, Staels B. PPARs in obesity-     doi: 10.1016/j.indcrop.2018.12.003
               induced T2DM, dyslipidaemia and NAFLD.  Nat Rev   47.  Korbecki J, Bobiński R, Dutka M. Self-regulation of the
               Endocrinol. 2017;13(1):36-49.
                                                                  inflammatory response by peroxisome proliferator-activated
               doi: 10.1038/nrendo.2016.135.                      receptors. Inflamm Res. 2019;68:443-458.


            Volume 3 Issue 4 (2024)                         12                                doi: 10.36922/td.4003
   50   51   52   53   54   55   56   57   58   59   60