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Tumor Discovery SNPs rs9929218 and rs6983267 in Kurdish CRC

Table 5. Comparison of clinic‑pathological features between wild‑type and mutant SNPs (rs9929218 and rs6983267)
Features Wild‑type SNPs Mutant SNPs Test Test statistics p p (multivariate
logistic regression)
Age (years) 67.54% (±2.31) 65.18 (±3.07) Mann–Whitney U-test U=4325.5 1.0 0.890
Gender (n)
Male 89 62 Chi-square χ =3.24 0.072 0.112
2
Female 97 42
Anatomical sites (n)
Colon 136 90 Chi-square χ =7.46 0.006* 0.049*
2
Rectum 51 13
Tumor size (cm) 3.48 (±0.33) 5.87 (±1.06) Mann–Whitney U U=277 <0.001* 0.038*
Tumor grade (n)
Low grade 124 50 Chi-square χ =2.76 0.097 0.41
2
High grade 71 45
Tumor stage (n)
T2 or earlier 105 34 Chi-square χ =24.55 <0.001* 0.031*
2
T3 or later 70 81
Nodal stage (n)
2
N0 60 11 Chi-square χ =13.52 0.001* 0.027*
N1 83 30
N2 63 43
TNM stage (n)
Stages 1 and 2 52 33 Chi-square χ =0.21 0.644 0.472
2
Stages 3 and 4 133 72
Perineural invasion (n)
Absent 151 36 Chi-square χ =45.89 <0.001* 0.015*
2
Present 42 61
Vascular invasion (n)
Absent 98 54 Chi-square χ =0.0 1.0 0.785
2
Present 89 49
Note: *p<0.05 (two-tailed significance).
Abbreviation: SNP: Single-nucleotide polymorphism.

4. Discussion for confounding factors such as age, sex, tumor grade,
and TNM staging, multivariate logistic regression did
CRC is a multifactorial disease influenced by both not support these associations (rs9929218: p=0.194;
genetic and environmental factors. Identifying genetic rs6983267: p=0.271). These findings suggest that while
polymorphisms associated with CRC susceptibility is
crucial for understanding disease pathogenesis and these SNPs may be more prevalent in CRC patients, their
improving risk stratification. In this study, we investigated associations with CRC susceptibility may be confounded
by other clinical variables.
the clinical relevance of two SNPs – rs9929218 in CDH1
and rs6983267 in the 8q24 region – among Kurdish CRC The rs9929218 polymorphism in CDH1 has been
patients in Al-Sulaymaniyah province, Iraq. Our initial previously associated with CRC risk, particularly in
univariate analysis suggested a significant association European populations. CDH1 encodes E-cadherin, a key
4,7
between both SNPs and CRC risk, with rs9929218 adhesion protein that regulates epithelial integrity, and
detected in 20.34% of CRC cases and 7% of controls its dysregulation is implicated in tumor progression and
(p=0.003), and rs6983267 found in 26.55% of CRC cases metastasis. 17,18 Some studies have suggested that rs9929218
and 11% of controls (p=0.002). However, after adjusting may affect E-cadherin expression or function, thereby

Volume 4 Issue 2 (2025) 87 doi: 10.36922/TD025110021