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Figure 3
Figure 3: Different Tumor Models Based on 3D printing Microfluidic Technology.
(A) (top) Schematic diagram of the migration behavior of aggressive cancer cells.
(Bottom) Application of microfluidics technology in the study of tumor invasion.
Including real-time imaging of cell-ECM interactions and biophysical changes,
controlled application of promigratory factors, pathomimetic TME construction and
organ-specific metastasis modeling. Adapted from ref.[69] (B) Biomimetic
microvascular network-on-chip for studying lung cancer metastasis. A diamond-shaped
central chamber harbors co-cultured endothelial cells, fibroblasts, and smooth muscle
cells within ECM gel, forming perfusable 3D vasculature. Flanking perfusion channels
deliver nutrients or cancer cells. Adapted from ref.[72] (C) Different types of 3D printed
molds for the production of 3D tumor spheroid models demonstrate the flexibility of
3D printing to produce microfluidic devices. Adapted from ref.[73]
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