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with an integrated vascularized tumor model and confocal microscopy images of the

                   chips  before  (Day  9)  and  after  (Day  12)  bevacizumab  treatment.  Left  panels  show

                   mRCC  spheroids  (non-fluorescent)  co-cultured  with  endothelial  cells  (red
                   fluorescence). Right panels show endothelial cells only (red fluorescence). Adapted

                   from ref.[98] (F) Illustration of the operating steps for using the 3D-printed versatile

                   tumor-on-a-chip for spheroid culture. Adapted from ref.[60]






































































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