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Figure 6
Figure 6: Advanced CTC Isolation Platforms Using 3D-Printed Microfluidics. (A)
Schematic of a rapid CTC processing chip featuring deterministic lateral displacement
for size-based enrichment, coupled with integrated cell handling modules for
downstream molecular analysis. Adapted with permission from ref.[119] (B) CTCelect
automated workflow for single-cell isolation. Positive selection of tumor cells and
subsequent WBC consumption and fluorophore-conjugated labeling were performed in
the enrichment module of the device. The enriched sample is then transferred to the cell
sorting subunit into a microfluidic chip for cell sorting and dispensing of single cells in
microliters droplets. Adapted with permission from ref.[120] (C) A new CTC capture
platform consisting of patterned SiNP substrates with high CTC affinity and serpentine
chaotic mixing channels with anti-EpCAM coatings enables efficient CTC capture
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