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Artificial Intelligence in Health ISM: A new multi-view space-learning model

Figure 5. Signature 915 Data: Clustering of cell type marker genes along ISM, MVMDS, NMF, NTF, MOFA+, and PCA components in the 2D scatterplots
of the MDS projection of the transformed data.
Abbreviations: Basophil LD: Low-density basophil; ISM: Integrated sources model; MAIT: Mucosal-associated invariant T cell; mDCs: Myeloid dendritic
cells; MOFA+: Multi-Omics Factor Analysis; Monocyte C: Classical monocyte; Monocyte NC+I: Non-classical + intermediate monocytes; MVMDS:
Multi-view multidimensional scaling; Neutrophil LD: Low-density neutrophil; NK: Natural killer cell; NMF: Non-negative matrix factorization; NTF:
Non-negative tensor factorization; PCA: Principal component analysis; pDCs: Plasmacytoid dendritic cells; VD2: Vδ2+ T cells.
Other methods, including ISM, revealed heterogeneity split in the corresponding UMAP projections. In the ISM
in the CD4+ naive T cell population, which appeared to be UMAP projection, we annotated the smaller split near

Volume 1 Issue 3 (2024) 102 doi: 10.36922/aih.3427