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Artificial Intelligence in Health                             Segmentation and classification of DR using CNN



            statement emphasizes the challenges in existing diagnostic   Writing-original draft: Manoj Saligrama Harisha, Arya
            methods and introduces datasets encompassing lesion   Arun Bhosale
            segmentation, disease/image grading, and LLMs for test/  Writing-review & editing: Manoj Saligrama Harisha, Arya
            treatment recommendations.                            Arun Bhosale
              Identifying research gaps, the paper underscores the   Ethics approval and consent to participate
            need for exploring the integration of pre-trained LLMs
            with segmented image data, emphasizing the potential   Not applicable.
            synergies between visual segmentation features and
            clinical classifications within a decision-support system.   Consent for publication
            Another research gap pertains to the dynamics of multi-  Not applicable.
            model integration, particularly in a web application context
            where lesion segmentations, disease classification, and   Availability of data
            LLMs collaborate. The objectives outline a comprehensive   Data for this study are sourced from two primary datasets:
            DR detection methodology, the integration of various   the APTOS 2019 Blindness Detection dataset, available
            models, performance evaluation, contribution to detection   on Kaggle.com, and the IDRiD, accessible through Grad-
            methodologies, and the identification and exploration of   Challenge.org. In addition, the code repository for the DR
            research gaps.                                     Detection and Classification System used in this research

              The research scope aims to revolutionize DR detection   can be found at https://github.com/Manoj-Sh-AI/Diabetic-
            methodologies by integrating cutting-edge technologies   Retinopathy-Detection-and-Clasification-System.
            and contributing to the wider field of medical imaging
            and automated diagnostics. The methods encompass data   Further disclosure
            pre-processing, data augmentation, network architecture   This paper has been uploaded and made publicly available
            detailing the U-Net model, and the training and testing   on a preprint server (arXiv:2401.02759), available at:
            processes. The results showcase the effectiveness of the   https://arxiv.org/abs/2401.02759
            segmentation model across various retinal structures,
            with high Jaccard scores, F1 scores, recall scores, precision   References
            scores,  and overall  accuracy, underscoring its  potential   1.  NCHS. Eye Disorders and Vision Loss among U.S. Adults
            for enhancing diagnostic capabilities in retinal pathology   Aged 45 and Over with Diagnosed Diabetes; 2019. Available
            assessment.                                           from: https://stacks.cdc.gov/view/cdc/80081 [Last accessed
                                                                  on 2024 Jul 11].
            Acknowledgments
                                                               2.   Pezzullo L, Streatfeild J, Simkiss P, Shickle D. The economic
            We would like to express our gratitude to our guide,   impact of sight loss and blindness in the UK adult population.
            Dr.  Narender M., Assistant Professor, Department of   BMC Health Serv Res. 2018;18:63.
            Computer Science and Engineering at the National      doi: 10.1186/s12913-018-2836-0.
            Institute of Engineering (NIE), for his invaluable guidance
            and support throughout the course of this research. His   3.   Hann CE, Chase JG, Revie JA, Hewett D, Shaw GM. Diabetic
            expertise and insightful feedback significantly contributed   retinopathy screening using computer vision.  IFAC Proc
            to the development of this work.                      Vol. 2009;42:298-303.
                                                                  doi: 10.3182/20090812-3-DK-2006.0086
            Funding
                                                               4.   Rohan TE, Frost CD, Wald NJ. Prevention of blindness
            None.                                                 by screening for diabetic retinopathy: A  quantitative
                                                                  assessment. BMJ. 1989;299:1198-1201.
            Conflict of interest
                                                                  doi: 10.1136/bmj.299.6709.1198
            The authors declare that they have no competing interests.  5.  SNEC. Singapore’s Eye Health; 2019. Available from: https://
                                                                  www.snec.com.sg [Last accessed on 2024 Jul 11].
            Author contributions
                                                               6.   Priya R, Aruna P. SVM and Neural Network Based Diagnosis
            Conceptualization: Manoj Saligrama Harisha, Arya Arun   of Diabetic Retinopathy; 2012. Available from: https://www.
               Bhosale                                            researchgate.net/publication/261177114_svm_and_neural_
            Investigation: All authors                            network_based_diagnosis_of_diabetic_retinopathy  [Last
            Methodology: Manoj Saligrama Harisha                  accessed on 2024 Jul 11].


            Volume 1 Issue 4 (2024)                         40                               doi:10.36922/aih.2783
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