Page 109 - AIH-2-1

Artificial Intelligence in Health EBNA1 inhibitors against EBV in NPC

10. Zhang L, Fourches D, Sedykh A, et al. Discovery of novel 21. Harris A, Young BD, Griffin BE. Random association of
antimalarial compounds enabled by QSAR-based virtual Epstein-Barr virus genomes with host cell metaphase
screening. J Chem Inf Model. 2013;53(2):475-492. chromosomes in Burkitt’s lymphoma-derived cell lines.
J Virol. 1985;56(1):328-332.
doi: 10.1021/ci300421n
doi: 10.1128/JVI.56.1.328-332.1985
11. Kamano Y, Yamashita A, Nogawa T, et al. QSAR evaluation
of the Ch’an Su and related bufadienolides against the 22. Petti L, Sample C, Kieff E. Subnuclear localization and
colchicine-resistant primary liver carcinoma cell line PLC/ phosphorylation of Epstein-Barr virus latent infection
PRF/5. J Med Chem. 2002;45(25):5440-5447. nuclear proteins. Virology. 1990;176(2):563-574.
doi: 10.1021/jm0202066 doi: 10.1016/0042-6822(90)90027-o
12. Avram S, Stan MS, Udrea AM, Buiu C, Boboc AA, Mernea M. 23. Lee MA, Diamond ME, Yates JL. Genetic evidence that
3D-ALMOND-QSAR models to predict the antidepressant EBNA-1 is needed for efficient, stable latent infection by
effect of some natural compounds. Pharmaceutics. Epstein-Barr virus. J Virol. 1999;73(4):2974-2982.
2021;13(9):1449. doi: 10.1128/jvi.73.4.2974-2982.1999
doi: 10.3390/pharmaceutics13091449 24. Lupton S, Levine AJ. Mapping genetic elements of Epstein-
13. Ravichandran V, Jain A, Mourya V, Agrawal RK. Prediction Barr virus that facilitate extrachromosomal persistence of
of anti-HIV activity and cytotoxicity of pyrimidinyl and Epstein-Barr virus-derived plasmids in human cells. Mol
triazinyl amines: A QSAR study. Chem Pap. 2008;62:596-602. Cell Biol. 1985;5:2533-2542.
doi: 10.2478/s11696-008-0072-5 doi: 10.1128/mcb.5.10.2533-2542.1985
14. Yuan H, Parrill AL. QSAR studies of HIV-1 integrase 25. Wood VHJ, O’Neil JD, Wei W, Stewart SE, Dawson CW,
inhibition. Bioorg Med Chem. 2002;10(12):4169-4183. Young LS. Epstein-Barr virus-encoded EBNA1
regulates cellular gene transcription and modulates the
doi: 10.1016/s0968-0896(02)00332-2 STAT1 and TGFbeta signaling pathways. Oncogene.
15. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, 2007;26(28):4135-4147.
Jemal A. Global cancer statistics 2018: GLOBOCAN doi: 10.1038/sj.onc.1210496
estimates of incidence and mortality worldwide for 36 cancers
in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. 26. Valentine R, Dawson CW, Hu C, et al. Epstein-Barr virus-
encoded EBNA1 inhibits the canonical NF-κB pathway in
doi: 10.3322/caac.21492 carcinoma cells by inhibiting IKK phosphorylation. Mol
16. Azizah AM, Hashimah B, Nirmal K, et al. Malaysia National Cancer. 2010;9:1.
Cancer Registry Report (MNCR). Putrajaya, Malaysia: doi: 10.1186/1476-4598-9-1
National Cancer Institute, Ministry of Health; 2019.
27. Sivachandran N, Sarkari F, Frappier L. Epstein-Barr
17. Devi BCR, Pisani P, Tang TS, Parkin DM. High incidence nuclear antigen 1 contributes to nasopharyngeal carcinoma
of nasopharyngeal carcinoma in native people of Sarawak, through disruption of PML nuclear bodies. PLoS Pathog.
Borneo Island. Cancer Epidemiol Biomarkers Prev. 2008;4(10):e1000170.
2004;13(3):482-486.
doi: 10.1371/journal.ppat.1000170
18. Yates J, Warren N, Reisman D, Sugden B. A cis-acting element
from the Epstein-Barr viral genome that permits stable 28. Scaglioni PP, Yung TM, Cai LF, et al. A CK2-dependent
replication of recombinant plasmids in latently infected mechanism for degradation of the PML tumor suppressor.
cells. Proc Natl Acad Sci U S A. 1984;81(12):3806-3810. Cell. 2006;126(2):269-283.
doi: 10.1073/pnas.81.12.3806 doi: 10.1016/j.cell.2006.05.041
19. Frappier L, O’Donnell M. Epstein-barr nuclear antigen 1 29. Sivachandran N, Cao JY, Frappier L. Epstein-Barr virus
mediates a DNA loop within the latent replication nuclear antigen 1 Hijacks the host kinase CK2 to disrupt
origin of Epstein-Barr virus. Proc Natl Acad Sci U S A. PML nuclear bodies. J Virol. 2010;84(21):11113-11123.
1991;88(23):10875-10879. doi: 10.1128/JVI.01183-10
doi: 10.1073/pnas.88.23.10875 30. Holowaty MN, Zeghouf M, Wu H, et al. Protein profiling
with Epstein-Barr nuclear antigen-1 reveals an interaction
20. Chaudhuri B, Xu H, Todorov I, Dutta A, Yates JL.
Human DNA replication initiation factors, ORC and MCM, with the herpesvirus-associated ubiquitin-specific protease
associate with oriP of Epstein-Barr virus. Proc Natl Acad Sci HAUSP/USP7. J Biol Chem. 2003;278(32):29987-29994.
U S A. 2001;98(18):10085-10089. doi: 10.1074/jbc.M303977200
doi: 10.1073/pnas.181347998 31. Gruhne B, Sompallae R, Marescotti D, Kamranvar SA,

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