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Artificial Intelligence in Health                            Federated learning health stack against pandemics



            reported for RT-PCR tests. A  more detailed analysis   architectures,  including  ResNet50,   SeResNext50, 31,32
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            revealed that EfficientNet exhibited the highest specificity   and  DenseNet161,   were  evaluated, with  DenseNet161
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            (95.4%) for COVID-19, while ResNet34 showed the highest   demonstrating the optimal performance. The CNN classifies
            sensitivity (94%). Interestingly, EfficientNet showed   each ROI as cancerous or non-cancerous, providing not
            the highest performance in classifying normal cases,   only diagnostic information but also, combined with the
            SeResNext50 excelled in classifying pneumonia cases, and   clustering results, an approximate segmentation mask. This
            ResNet34 was most effective for COVID-19 cases. These   approach bypasses the need for computationally intensive
            results are comparable to, and in some cases outperform,   semantic segmentation techniques, such as GrabCut  or
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            those reported in earlier studies using CNNs for COVID-19   context-aware masks,  offering a more efficient method
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            detection from chest X-rays and computed tomography   for identifying and localizing cancerous nodules within
            (CT) scans. 37-39  The present deep-learning approach offers   the lung.
            advantages in terms of speed, resource efficiency, and
            potentially greater accuracy compared to RT-PCR. The   2.8. Public data authentication and blockchain
            approach is particularly appealing for resource-limited   The previous section discussed the need to ensure a smooth
            settings  where  rapid  screening  is  critical.  Moreover,  the   communication protocol between the central server, local
            decoupled workflow, separating image acquisition and   servers, and data-owning entities, which necessitates
            diagnostic evaluation, offers greater operational flexibility   entering  into  a  legal  contract  between  the  parties.  It  is
            and scalability, aligning with the principles outlined in the   important to note that, ideally, the central server should be
            previous study  for building a robust pandemic response.  owned either directly by the United Nations or any of its
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              A previous study  explored a novel approach for   subsidiaries, such as the WHO. Due to the lack of specific
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            lung cancer detection, combining an unsupervised   sovereign oversight over the entire protocol, creating digital
            clustering algorithm for ROI proposals with CNNs. 41,42    trust is imperative. Fortunately, a robust technical solution
            The modularity optimization-based  graph clustering   is available to build trust in the digital space between
            method 41,42   applied  to  preprocessed  CT  scans  from  the   unknown agencies through a decentralized protocol called
            2016 lung nodule analysis dataset 43,44  reduces CNN   blockchain. Blockchain-based smart contracts offer an
            complexity by identifying potential nodule locations.   attractive method that creates a transparent technological
            This preprocessing step includes lung segmentation using   framework governing the relations between the parties
            marker-controlled “watershed segmentation” on Sobel-  participating in the FL architecture. However, such smart
            filtered images, focusing the analysis on relevant areas and   contracts are not free from threats, and in the following, a
            reducing the computational burden. The segmented lung   few novel methods to ensure data safety in smart contracts
            regions are then converted into a network, with pixels   are discussed.
            representing nodes and edges connecting neighboring
            pixels. This network is then clustered using a modularity   Detecting vulnerabilities in smart contracts is crucial
            function optimized for spatially embedded networks, 41,42    due to their immutable nature and the potential for
            which has been successfully used previously in analyzing   significant financial losses, as evidenced by past incidents,
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            granular assemblies.   This method  effectively  identifies   including the decentralized autonomous organization
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            nodules based on grayscale-intensity similarity, generating   hack and the Parity wallet freeze.  Gogineni  et al.
            ROI proposals for subsequent CNN analysis.         constructed a multiclass classifier to detect vulnerabilities
                                                               in smart contracts by fine-tuning an AWD-LSTM model.
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              The proposed method utilizes these ROI proposals   The  model  was fine-tuned  using  a dataset  of  40,877
            to streamline the CNN classification process. Rather   unique opcode combinations from smart contracts.
            than relying on computationally expensive selective   The smart contracts were classified into four categories:
            search  or fully labeled datasets required for methods   suicidal, prodigal, greedy, and normal. To address the
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            like MaskRCNN,  this approach employs the clustering   class imbalance, only distinct opcode combinations were
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            algorithm to generate a manageable number of fixed-size   retained for normal smart contracts, as they comprised
            ROIs. These ROIs are then fed into a CNN, trained using   the majority of the dataset and often contained repeated
            transfer learning initialized with ImageNet weights,  and   sequences.
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            optimized using  learning  rate  scheduler techniques.
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            This training strategy, employing discriminative learning   The AWD-LSTM model architecture combined a
            rates for different layers of the network, facilitates efficient   pretrained encoder with  a custom classification  head,
            learning of both general and dataset-specific features,   inspired by the ULMFiT method  used in natural
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            which are  of great value  for the FL learning protocols   language processing. This method achieved an overall
            discussed in this article. Several pre-trained CNN   accuracy of 91.3% and a weighted average F1 score of
            Volume 2 Issue 4 (2025)                         83                          doi: 10.36922/AIH025080013
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