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Advanced Neurology                                                   PVT in Indonesian neurological patients




            Table 6. Participants who failed at least two performance validity tests
            Participant ID   Demographic information      MMSE score     Comorbid                PVT failure
            ND
             32              Male, 79 years, elementary education  25    -                       LDF-1, NV-MSVT
             87              Male, 68 years, secondary education  26     Diabetes and high cholesterol  TMJPI, NV-MSVT
            PS
             106             Male, 33 years, elementary education  26    -                       TMJPI, NV-MSVT
            Mixed-etiology
             130 a           Female, 55 years, tertiary education  -     Post-stroke             RDS, TMJPI
            Note:  The participant’s primary diagnosis was brain tumor-related epilepsy (focal onset with impaired awareness).
                a
            Abbreviations: LDF-1: Longest digit forward-1 trial; MMSE: Mini-mental state examination; ND: Neurocognitive disorder group due to possible
            neurodegenerative disease; NV-MSVT: Non-verbal medical symptom validity test; PS: Post-stroke group; PVT: Performance validity test; RDS: Reliable
            digit span; TMJPI: Tes Memori Jangka Pendek Indonesia.
            Table 7. Intercorrelation coefficients between performance validity tests and correlation coefficients between demographic
            variables, MMSE scores, and performance validity test scores
            Parameter                   RDS         LDF‑1      LDF‑2      TMJPI              NV‑MSVT
                                                                                     Criterion A1  Criterion A2
            Performance validity test
             RDS                         -            -          -          -            -             -
             LDF-1                      0.61*         -          -          -            -             -
             LDF-2                      0.81*        0.67*       -          -            -             -
             TMJPI                      0.35*        0.47*      0.30*       -            -             -
             Criterion A1 NV-MSVT       0.34*        0.38*      0.33*      0.52*         -             -
             Criterion A2 NV-MSVT       0.31*        0.32*      0.29*      0.46*        0.97*          -
            Demographic variables
             Gender                     −0.03        0.09       0.07       0.03        −0.10         −0.08
             Age                        −0.14       −0.31*      −0.14     −0.34*       −0.42*        −0.36*
             Education                  0.27*        0.23*      0.21*      0.29*        0.21*         0.20*
             MMSE a                     0.43*        0.44*      0.42*      0.63*        0.56*         0.49*
            Note: *P<0.05.  The correlational analyses for the MMSE were performed only for the neurocognitive disorder and post-stroke groups.
                      a
            Abbreviations: LDF-1: Longest digit forward-1 trial; LDF-2: Longest digit forward-2 trials; MMSE: Mini-mental state examination;
            NV-MSVT: Non-verbal medical symptom validity test; RDS: Reliable digit span; TMJPI: Tes memori jangka pendek Indonesia.

            patient groups generally perform worse on PVTs compared   Examination  of  the  specificity  rate  for  the  RDS
            to healthy volunteers.  Specifically, compared to healthy   showed that the cut-off scores (≤7) from the previous
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            participants,  the ND group scored disproportionately lower   simulation  study   could  not  be  applied  to  our  clinical
                      22
            on the embedded PVTs than on the standalone PVTs. This   sample. This recommended RDS cut-off score was even
                                                                                                            32
            may be due to the a posteriori approach used in embedded   higher than the traditional RDS cut-off score (≤6).
            PVTs, which makes them more susceptible to failure in cases   Our RDS cut-off score for the PS and mixed-etiology
            of severe cognitive dysfunction.  Some studies have shown   groups (≤4) was lower than those used in other studies
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            that the diagnostic accuracy of standalone PVTs tends to   with mixed neurological samples, which have suggested
                                                               ≤5.
                                                                      Further adjustment was needed for the RDS in
                                                                 18,54,55
            be  better than that of  embedded PVTs. 17,48,49  Consistent   our mild and major ND groups (i.e., ≤3). In some studies,
            with our hypotheses, the ND group performed significantly   the traditional cut-off score for the RDS has resulted in a
            worse than the PS and mixed-etiology groups. In addition,   specificity rate below 0.90 in people with dementia. 9,50-52
            the mild ND group scored higher than the major ND group,   Consistent with our results, other studies have also
            indicating that more severe cognitive dysfunction negatively   suggested lowering the RDS cut-off score to ≤3 to achieve
            affects PVT scores, particularly for embedded PVTs. 1,12,50-53  a specificity rate above 0.90. 21

            Volume 4 Issue 2 (2025)                         93                               doi: 10.36922/an.5661
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