Page 103 - AN-4-3
P. 103

Advanced Neurology                                            TG100-115 suppresses glioblastoma cell functions



            Author contributions                                  doi: 10.1016/j.ctrv.2019.101896

            Conceptualization:  Hong-Shuo Sun, Zhong-Ping Feng,   7.   Fleig A, Chubanov V. TRPM7. In: Nilius B, Flockerzi V,
               Wenliang Chen                                      editors.  Mammalian Transient Receptor Potential (TRP)
            Formal analysis: Yuanyuan Xu, Rahmah Alanazi          Cation Channels. Vol. 1. Berlin, Heidelberg: Springer; 2014.
                                                                  p. 521-546.
            Investigation: Yuanyuan Xu, Wenliang Chen
            Methodology: Yuanyuan Xu, Wenliang Chen            8.   Yee NS, Kazi AA, Li Q, Yang Z, Berg A, Yee RK. Aberrant
            Writing–original draft: Yuanyuan Xu, Xinyang Zhang, Erin   over-expression of TRPM7 ion channels in pancreatic
               Cross, Barbara Gundi                               cancer: Required for cancer cell invasion and implicated in
            Writing–review & editing:  Hong-Shuo Sun, Zhong-Ping   tumor growth and metastasis. Biol Open. 2015;4(4):507-514.
               Feng, James T. Rutka, F. David Horgen, Andrea Fleig     doi: 10.1242/bio.20137088
                                                               9.   Guilbert A, Gautier M, Dhennin-Duthille I, Haren N,
            Ethics approval and consent to participate            Sevestre H, Ouadid-Ahidouch H. Evidence that TRPM7 is
            Not applicable.                                       required for breast  cancer  cell  proliferation.  Am J Physiol
                                                                  Cell Physiol. 2009;297(3):C493-C502.
            Consent for publication                               doi: 10.1152/ajpcell.00624.2008

            Not applicable.                                    10.  Kim BJ, Park EJ, Lee JH, Jeon JH, Kim SJ, So I.
                                                                  Suppression of transient receptor potential melastatin 7
            Availability of data                                  channel induces cell death in gastric cancer. Cancer Sci.
            The data supporting this study can be accessed by     2008;99(12):2502-2509.
            submitting a request to the lead or corresponding author.     doi: 10.1111/j.1349-7006.2008.00982.x
            References                                         11.  Chen JP, Luan Y, You CX, Chen XH, Luo RC, Li R.
                                                                  TRPM7 regulates the migration of human nasopharyngeal
            1.   Wasilewski A, Serventi J, Kamalyan L, Wychowski T,   carcinoma  cell  by mediating  Ca(2+)  influx.  Cell Calcium.
               Mohile N. Acute care in glioblastoma: The burden and the   2010;47(5):425-432.
               consequences. Neurooncol Pract. 2017;4(4):248-254.
                                                                  doi: 10.1016/j.ceca.2010.03.003
               doi: 10.1093/nop/npw032
                                                               12.  Chen WL, Barszczyk A, Turlova E, et al. Inhibition of TRPM7
            2.   Stupp R, Hegi ME, Mason WP, et al. Effects of radiotherapy   by carvacrol suppresses glioblastoma cell proliferation,
               with concomitant and adjuvant temozolomide versus   migration and  invasion.  Oncotarget. 2015;6(18):16321-
               radiotherapy  alone  on  survival  in  glioblastoma  in  a   16340.
               randomised phase III study: 5-year analysis of the EORTC-
               NCIC trial. Lancet Oncol. 2009;10(5):459-466.      doi: 10.18632/oncotarget.3872
                                                               13.  Wong R, Gong H, Alanazi R, et al. Inhibition of TRPM7
               doi: 10.1016/S1470-2045(09)70025-7
                                                                  with waixenicin A reduces glioblastoma cellular functions.
            3.   Kannan S, Murugan AK, Balasubramanian S, Munirajan AK,   Cell Calcium. 2020;92:102307.
               Alzahrani AS. Gliomas: Genetic alterations, mechanisms of      doi: 10.1016/j.ceca.2020.102307
               metastasis, recurrence, drug resistance, and recent trends
               in  molecular  therapeutic  options.  Biochem Pharmacol.   14.  Wong R, Turlova E, Feng ZP, Rutka JT, Sun HS. Activation
               2022;201:115090.                                   of TRPM7 by naltriben enhances migration and invasion of
                                                                  glioblastoma cells. Oncotarget. 2017;8(7):11239-11248.
               doi: 10.1016/j.bcp.2022.115090
                                                                  doi: 10.18632/oncotarget.14496
            4.   Murugan  AK,  Alzahrani  AS.  Isocitrate  dehydrogenase
               IDH1 and IDH2 mutations in human cancer: Prognostic   15.  Majewska  E, Szeliga M.  AKT/GSK3β signaling in
               implications for gliomas. Br J Biomed Sci. 2022;79:10208.  glioblastoma. Neurochem Res. 2017;42(3):918-924.
               doi: 10.3389/bjbs.2021.10208                       doi: 10.1007/s11064-016-2044-4
            5.   Murugan AK, Kannan S, Alzahrani AS. Immune checkpoint   16.  McCubrey JA, Steelman LS, Chappell WH,  et al. Roles
               expression  and  therapeutic  implications  in  IDH1-  of  the  Raf/MEK/ERK  pathway  in  cell  growth,  malignant
               mutant  and  wild-type  glioblastomas.  Curr Probl Cancer.   transformation and drug resistance. Biochim Biophys Acta.
               2025;55:101182.                                    2007;1773(8):1263-1284.
               doi: 10.1016/j.currproblcancer.2025.101182         doi: 10.1016/j.bbamcr.2006.10.001
            6.   Le Rhun E, Preusser M, Roth P, et al. Molecular targeted   17.  Chen WL, Turlova E, Sun CL, et al. Xyloketal B suppresses
               therapy of glioblastoma. Cancer Treat Rev. 2019;80:101896.  glioblastoma cell proliferation and migration  in vitro


            Volume 4 Issue 3 (2025)                         97                           doi: 10.36922/AN025110023
   98   99   100   101   102   103   104   105   106   107   108