Page 104 - AN-4-3

Advanced Neurology TG100-115 suppresses glioblastoma cell functions

through inhibiting TRPM7-regulated PI3K/Akt and MEK/ cancer. Semin Cancer Biol. 2019;59:1-2.
ERK signaling pathways. Mar Drugs. 2015;13(4):2505-2525.
doi: 10.1016/j.semcancer.2019.10.022
doi: 10.3390/md13042505
29. Bravo-Cordero JJ, Magalhaes MA, Eddy RJ, Hodgson L,
18. Tian Y, Yang T, Yu S, Liu C, He M, Hu C. Prostaglandin E2 Condeelis J. Functions of cofilin in cell locomotion and
increases migration and proliferation of human glioblastoma invasion. Nat Rev Mol Cell Biol. 2013;14(7):405-415.
cells by activating transient receptor potential melastatin 7 doi: 10.1038/nrm3609
channels. J Cell Mol Med. 2018;22(12):6327-6337.
30. Manning BD, Cantley LC. AKT/PKB signaling: Navigating
doi: 10.1111/jcmm.13931
downstream. Cell. 2007;129(7):1261-1274.
19. Meng S, Alanazi R, Ji D, et al. Role of TRPM7 kinase in doi: 10.1016/j.cell.2007.06.009
cancer. Cell Calcium. 2021;96:102400.
31. Hoeger B, Nadolni W, Hampe S, et al. Inactivation of
doi: 10.1016/j.ceca.2021.102400
TRPM7 kinase targets AKT signaling and cyclooxygenase-2
20. Guilbert A, Gautier M, Dhennin-Duthille I, et al. expression in human CML cells. Function (Oxf).
Transient receptor potential melastatin 7 is involved in 2023;4(6):zqad053.
oestrogen receptor-negative metastatic breast cancer doi: 10.1093/function/zqad053
cells migration through its kinase domain. Eur J Cancer.
2013;49(17):3694-707. 32. Nadolni W, Immler R, Hoelting K, et al. TRPM7 kinase
is essential for neutrophil recruitment and function
doi: 10.1016/j.ejca.2013.07.008
via regulation of Akt/mTOR signaling. Front Immunol.
21. Wan J, Guo AA, Chowdhury I, et al. TRPM7 induces 2020;11:606893.
mechanistic target of rap1b through the downregulation doi: 10.3389/fimmu.2020.606893
of miR-28-5p in glioma proliferation and invasion. Front
Oncol. 2019;9:1413. 33. Pridham KJ, Le L, Guo S, et al. PIK3CB/p110beta is a
selective survival factor for glioblastoma. Neuro Oncol. Mar
doi: 10.3389/fonc.2019.01413
27 2018;20(4):494-505.
22. Song C, Bae Y, Jun J, et al. Identification of TG100-115 as a doi: 10.1093/neuonc/nox181
new and potent TRPM7 kinase inhibitor, which suppresses
breast cancer cell migration and invasion. Biochim Biophys 34. Zhao HF, Wang J, Jiang HR, Chen ZP, To SS. PI3K
Acta Gen Subj. Apr 2017;1861(4):947-957. p110β isoform synergizes with JNK in the regulation of
glioblastoma cell proliferation and migration through Akt
doi: 10.1016/j.bbagen.2017.01.034
and FAK inhibition. J Exp Clin Cancer Res. 2016;35:78.
23. Doukas J, Wrasidlo W, Noronha G, et al. Phosphoinositide doi: 10.1186/s13046-016-0356-5
3-kinase gamma/delta inhibition limits infarct size after
myocardial ischemia/reperfusion injury. Proc Natl Acad Sci 35. Yuan J, Dong X, Yap J, Hu J. The MAPK and AMPK
U S A. 2006;103(52):19866-19871. signalings: Interplay and implication in targeted cancer
therapy. J Hematol Oncol. 2020;13(1):113.
doi: 10.1073/pnas.0606956103
doi: 10.1186/s13045-020-00949-4
24. Alandağ C, Kancaği DD, Karakuş Sir G, et al. The effects of
thymoquinone on pancreatic cancer and immune cells. Rev 36. Barbosa R, Acevedo LA, Marmorstein R. The MEK/ERK
Assoc Med Bras (1992). 2022;68(8):1023-1026. network as a therapeutic target in human cancer. Mol Cancer
Res. 2021;19(3):361-374.
doi: 10.1590/1806-9282.20220066
doi: 10.1158/1541-7786.MCR-20-0687
25. Asadi M, Taghizadeh S, Kaviani E, et al. Caspase-3:
Structure, function, and biotechnological aspects. Biotechnol 37. Qiu B, Wang Y, Tao J, Wang Y. Expression and correlation of
Appl Biochem. 2022;69(4):1633-1645. Bcl-2 with pathological grades in human glioma stem cells.
Oncol Rep. 2012;28(1):155-160.
doi: 10.1002/bab.2233
doi: 10.3892/or.2012.1800
26. Fulda S. Cell death-based treatment of glioblastoma. Cell
Death Dis. 2018;9(2):121. 38. Kirkin V, Joos S, Zornig M. The role of Bcl-2 family members
in tumorigenesis. Biochim Biophys Acta. 2004;1644(2-
doi: 10.1038/s41419-017-0021-8
3):229-249.
27. Murugan AK. mTOR: Role in cancer, metastasis and drug doi: 10.1016/j.bbamcr.2003.08.009
resistance. Semin Cancer Biol. 2019;59:92-111.
39. Fels C, Schafer C, Huppe B, et al. Bcl-2 expression in higher-
doi: 10.1016/j.semcancer.2019.07.003
grade human glioma: A clinical and experimental study.
28. Murugan AK. Special issue: PI3K/Akt signaling in human J Neurooncol. 2000;48(3):207-216.

Volume 4 Issue 3 (2025) 98 doi: 10.36922/AN025110023