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Advanced Neurology

SHORT COMMUNICATION
Alzheimer´s disease and related dementia

as a component of a multiorgan senescence
syndrome

Stephen J. Peroutka*

PPD Clinical Research Business of Thermo Fisher Scientific, 168 3 Ave, Waltham, Massachusetts,
rd
United States of America

Abstract

Patients with Alzheimer’s disease and related dementia (ADRD) have a higher risk
for comorbidities than non-cognitively impaired age-matched individuals. Because
ADRD is an age-related disorder, it was hypothesized that younger patients with ADRD
have a lower prevalence of comorbidities than their older counterparts. To test this
hypothesis, the following four patient cohorts were defined in the TriNetX Analytics
Network database based on the presence or absence of International Classification
of Diseases, Tenth Revision (ICD-10) codes G30 (Alzheimer’s disease), and/or F01
(dementia in other diseases classified elsewhere) in their health care records who had
health care visits from 2021 to 2023: individuals aged 65 – 80 years with and without
ADRD diagnosis and individuals aged ≥90 years with and without ADRD diagnosis.
Patients with ADRD in both age groups had a higher prevalence of comorbidities in
*Corresponding author: almost all ICD-10 chapters than age-matched non-ADRD individuals. The younger
Stephen J. Peroutka ADRD cohort showed a comorbidity pattern that was significantly different than that
(drperoutka@gmail.com) of their age-matched cohort (p < 0.0001); however, it was not statistically different than
Citation: Peroutka SJ. Alzheimer’s the comorbidity pattern of the older ADRD cohort (p = 0.80). Similarly, the younger
disease and related dementia non-ADRD cohort showed a comorbidity pattern that was not statistically different
as a component of a multiorgan
senescence syndrome. Adv Neuro. than that of the older non-ADRD cohort (p = 0.28). These results indicated that ADRD
2025;4(3):100-109. diagnosis is associated with coincident multiorgan dysfunction in a pattern that is
doi: 10.36922/an.4046 almost identical between the two different age groups. These data also suggested
Received: June 25, 2024 that cognitive impairment associated with ADRD is only a single component of a
multiorgan senescence syndrome. Overall, this study revealed that optimizing the
Revised: October 16, 2024
health care management of non-cognitive organ dysfunction in patients with ADRD
Accepted: November 13, 2024 may improve their overall health and, thereby, delay the progression of cognitive
Published online: November 29, impairment.
2024
Copyright: © 2024 Author(s). Keywords: Alzheimer’s disease; Dementia; Comorbidities; Multiorgan; Senescence;
This is an Open-Access article
distributed under the terms of the Syndrome
Creative Commons Attribution
License, permitting distribution,
and reproduction in any medium,
provided the original work is
properly cited. 1. Introduction
Publisher’s Note: AccScience Alzheimer’s disease and related dementia (ADRD) is a progressive neurodegenerative
Publishing remains neutral with condition that can lead to a significant decline in cognitive function. Over the past few
regard to jurisdictional claims in
published maps and institutional decades, extensive research has focused on potential therapies aimed at delaying or
affiliations. stopping the progression of cognitive decline associated with ADRD. Although treatments

Volume 4 Issue 3 (2025) 100 doi: 10.36922/an.4046