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Advances in Radiotherapy
            & Nuclear Medicine                                                             NCRT for T3N0M0 ESCC



            Appendix


            Table A1. Univariate and multivariate Cox regression analyses for the overall survival of the entire cohort after PSM
            Variables                                     Univariate                        Multivariate
                                                  HR (95% CI)        P‑value        HR (95% CI)        P‑value
            Age (years) >65 versus≤65            1.91 (1.18 – 3.07)   0.009        1.89 (1.17 – 3.06)   0.009
            Sex: Female versus Male              1.12 (0.60 – 2.08)   0.729
            KPS: 80 versus≥90                    1.31 (0.67 – 2.57)   0.450
            Weight loss: No versus Yes           0.85 (0.51 – 1.41)   0.524
            Tumor location                                            0.545
             Upper                               1.00 (reference)
             Middle                              0.75 (0.39 – 1.43)
             Lower                               0.70 (0.38 – 1.30)
            Tumor length (cm): >5 versus≤5       2.10 (0.66 – 6.70)   0.261
            LVI: No versus Yes                   0.86 (0.12 – 6.25)   0.886
            PNI: No versus Yes                   0.98 (0.49 – 1.98)   0.958
            Total lymph nodes excised: ≥18 versus<18  0.49 (0.30 – 0.82)  0.005    0.47 (0.28 – 0.79)   0.004
            Group: NCRT+S versus surgery         0.59 (0.36 – 0.98)   0.039        0.57 (0.34 – 0.94)   0.028
            Note: P<0.05 indicates statistically significant differences.
            Abbreviations: CI: Confidence intervals; HR: Hazard ratio; KPS: Karnofsky Performance Status; LVI: Lymphovascular invasion; NCRT+S: Neoadjuvant
            chemoradiotherapy plus surgery; PNI: Perineural invasion.













































            Volume 2 Issue 3 (2024)                         13                             doi: 10.36922/arnm.3821
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