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Brain & Heart                                                      Application of the neural networks surgery



            complexity and high incidence of cerebrovascular disease,   different parts of the brain is often centered on Broca’s
            innovations to traditional interventions and new programs   approach . Ever since diaschisis was first described by
                                                                      [14]
            are necessary.                                     von Monakov, many studies have focused on the possibility
              Neurosurgery aims to preserve brain function, while   that stroke does not only affect the function of focal areas,
                                                                                                    [15]
            managing lesions effectively. In the process of vascular   but also the region far from the local damage . Resting-
            malformation  resection,  aneurysm  clipping,  and  nerve   state FC can be used to prove network topography.
            interventional therapy, the brain function should be   Recently, the application of resting-state FC measurement
            preserved as much as possible to ensure a satisfactory   has made great progress in discovering the effects of stroke
            quality of life . Nowadays, with the application of novel   on brain networks and the causal effect of linkage deficits
                       [12]
                                                                                     [16,17]
            neural imaging equipment and microsurgery techniques,   on behavioral abnormalities  .
            the prognosis of patients has considerably improved .   In a study, after measuring the attention and motor
                                                        [13]
            With the advancements in treatment methods, cognitive   deficits in right hemisphere-damaged patients, Baldassarre
            protection has gained widespread attention in the field of   et al. found that the most common and robust disruption
            neurosurgery, especially in cerebrovascular diseases. With   are  a decrement of  interhemispheric  connectivity in
            the explosion of human connectome and neural networks   brain networks, thereby concluding that attention
            surgery, combining cerebrovascular disease treatment   deficits are significantly more correlated with abnormal
            with brain networks has been a subject of interest. Neural   interhemispheric FC within the dorsal attention network,
            networks surgery aims to improve the efficiency of neural   while motor deficits are significantly correlated with
            function and  cognitive  protection  by stabilizing the   abnormal motor networks. This study further deepens our
            complex network. This new insight has been applied to   understanding of stroke-related behavioral deficits .
                                                                                                       [14]
            numerous studies, contributing to preoperative planning,   Cerebral microbleeds (CMBs) are small foci of chronic
            intraoperative brain function protection, and post-  brain hemorrhages that are caused by the structural
            operative prognosis assessment in the neurosurgical field.   malformation of small blood vessels and the deposits of
            However, the application of this concept in cerebrovascular   blood products. They are often related to stroke  and
                                                                                                       [18]
            disease is in the early stage. Therefore, it is imperative   are always accompanied by dysfunction, dementia, and
            to continue to explore and improve the application of   cognitive impairment . Therefore, pre-symptomatic
                                                                                 [19]
            cognitive-related  brain networks  analysis technology,   detection of CMBs may help relieve the enormous burdens
            protection methods, and  intervening  measures.  We  aim   on hospitals and patients. Al-Masni et al. have proposed
            to review the application of the neural networks surgery   a fully automated two-stage integrated deep learning
            concept in the treatment of cerebrovascular disease from   approach for efficient CMB detection, a regional-based
            three  aspects  (disease  mechanism,  progression,  and   You Only Look Once network for potential CMB candidate
            the new strategies in neurosurgery for cerebrovascular   detection,  and  a  three-dimensional  convolutional  neural
            disease) and describe its effect on prognosis and plasticity   network for reducing false positives . Conventionally,
                                                                                             [20]
            maintenance.
                                                               in the study of CMB formation, Perls’ Prussian blue stain
            2. A deeper understanding of disease               is often used in the histological analysis of fixed tissue
                                                                     [21]
            pathogenesis and improvement in                    sections . This deep learning approach significantly
                                                               increases the accuracy of CMB detection and decreases
            diagnosis                                          the false positive rate. In their research, Crouzet  et al.,
            As the concept of brain networks emerges in the field   aiming at the advances in digital pathology, developed and
            of neurology, we gain a deeper understanding of the   compared three digital pathology approaches to identify
            pathogenesis of certain cerebrovascular diseases, thus   and quantify CMBs from sections stained with Prussian
            filling in the gaps of prior ones, including some classical   blue; they concluded that the deep learning approach is
            diseases, such as moyamoya disease (MMD), intracranial   more precise than the ratiometric approach, but the latter
            aneurysm (IA), and even the accompanying symptoms   has higher accuracy and versatility . The deep learning
                                                                                           [22]
            after stroke. Along with advanced medical techniques,   approach can certainly be referred to as another CMB
            this new concept has brought about a great deal of disease   diagnosis improvement.
            diagnosis methods. In this section, we discuss some novel   IA rupture often leads to a dismal prognosis or even
            achievements in disease mechanism following advanced   death. Several studies have reported that in the general
            diagnosis methods.                                 population, the morbidity of IAs has increased to more than
              Over centuries, the answer to how certain cognitive   5%. However, IAs that are small in size or with low-intensity
            operations are affected by local structural damage to   contrast to normal vessels in medical imaging scans are


            Volume 1 Issue 1 (2023)                         3                       https://doi.org/10.36922/bh.v1i1.223
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