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Brain & Heart Impact of ketogenic diet in adults with drug-resistant epilepsy

Conflict of interest 6. Neal EG, Chaffe H, Schwartz RH, et al. The ketogenic diet
for the treatment of childhood epilepsy: A randomised
There are no conflicts of interest to declare. controlled trial. Lancet Neurol. 2008;7(6):500-506.
Author contributions doi: 10.1016/S1474-4422(08)70092-9

Conceptualization: Huixin Liu, Hongjuan Lu, Wei Sun 7. Freeman JM, Vining EP, Kossoff EH, Pyzik PL, Ye X,
Goodman SN. A blinded, crossover study of the efficacy of
Data curation: Huixin Liu, Yichen Ji, Wenjian Liu, Haoran the ketogenic diet. Epilepsia. 2009;50(2):322-325.
Yang, Xuan Zhang, Jiayi Li
Methodology: Huixin Liu doi: 10.1111/j.1528-1167.2008.01740.x
Software: Huixin Liu 8. Dressler A, Stocklin B, Reithofer E, et al. Long-term outcome
Writing – original draft: Huixin Liu and tolerability of the ketogenic diet in drug-resistant
Writing – review and editing: Huixin Liu, Wei Sun childhood epilepsy--the Austrian experience. Seizure.
2010;19(7):404-408.
Ethics approval and consent to participate doi: 10.1016/j.seizure.2010.06.006

The study protocol was reviewed and approved by the 9. Green SF, Nguyen P, Kaalund-Hansen K, Rajakulendran S,
Ethics Review Board of Xuanwu Hospital, Capital Medical Murphy E. Effectiveness, retention, and safety of modified
University (Ethics Number: 2022231). Written informed ketogenic diet in adults with epilepsy at a tertiary-care
consent was obtained from all the participants and their centre in the UK. J Neurol. 2020;267(4):1171-1178.
guardians. doi: 10.1007/s00415-019-09658-6
Consent for publication 10. Kverneland M, Molteberg E, Iversen PO, et al. Effect
of modified Atkins diet in adults with drug-resistant
Written permission was obtained from patients to publish focal epilepsy: A randomized clinical trial. Epilepsia.
their data. 2018;59(8):1567-1576.

Availability of data doi: 10.1111/epi.14457
11. IJff DM, Postulart D, Lambrechts DA, et al. Cognitive
The data are not publicly available due to privacy and behavioral impact of the ketogenic diet in children
restrictions. The data that support the findings of this and adolescents with refractory epilepsy: A randomized
study are available from the corresponding author upon controlled trial. Epilepsy Behav. 2016;60:153-157.
reasonable request. doi: 10.1016/j.yebeh.2016.04.033
References 12. Zhu D, Wang M, Wang J, et al. Ketogenic diet effects on
neurobehavioral development of children with intractable
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resistant epilepsy: Consensus proposal by the ad hoc Task
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16. Sun Y, Seneviratne U, Perucca P, et al. Generalized polyspike
5. Wheless JW. History of the ketogenic diet. Epilepsia. train: An EEG biomarker of drug-resistant idiopathic
2008;49(Suppl 8):3-5. generalized epilepsy. Neurology. 2018;91(19):e1822-e1830.
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