Page 214 - EJMO-9-2

Eurasian Journal of
Medicine and Oncology Tetramethyl thyroxine boosts bladder cancer

A D

B

C

Figure 5. T4 promotes tumor growth in bladder cancer xenograft models. (A) Schematic diagram of tumor resection after T4 treatment. (B) T4 promotes
tumor volume growth in xenograft tumor models. (C) Increase in tumor weight after 30 days of T4 treatment. (D) The T4 treatment process detected an
increase in T4 and T3 levels and a decrease in TSH levels in the serum of mice. Notes: n = 5; *p<0.05; **p<0.01.
Abbreviation: TSH: Thyroid-stimulating hormone.

promotes cell proliferation through the ER by a MAPK- Wang et al. demonstrated that TRα transcript levels were
dependent pathway. In THCA, the interaction of T4 significantly increased in primary liver cancer. Further
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with integrins leads to the inhibition of TP53-dependent research revealed that T4 activated the NF-κB signaling
apoptosis in tumor cells. Meng et al. found that T4 pathway to initiate the expression of the BMI1 gene and
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increased proliferating cell nuclear antigen-induced ERα promote the self-renewal of liver cancer stem cells. 10
phosphorylation and promoted the proliferation of NCI- We initially observed through CCK-8 experiments
H522 and NCI-H510A lung cancer cells. Research by that the proliferation of BC T24 and EJ-1 cells increased
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Volume 9 Issue 2 (2025) 206 doi: 10.36922/EJMO025080037