Page 183 - EJMO-9-3

Eurasian Journal of
Medicine and Oncology Research on DSY in treating gastritis

A B

D
C

Figure 5. Optimization of key MS parameters for DSY decoction analysis. (A) Effect of spray voltage on peak area. (B) Effect of capillary temperature
on peak area. (C) Effect of auxiliary gas temperature on peak area. (D) Distribution map of detected precursor ions in positive and negative ion modes.
Abbreviations: Cry: Cryptotanshinone; Dih: Dihydrotanshinone I; DSY: Dan-Shen-Yin; Epi: Epicatechin; II A: Tanshinone IIA; MS: Mass spectrometry;
NEG: Negative ion mode; Ori: Orientin; POS: Positive ion mode; SalA: Salvianolic acid A; SalB: Salvianolic acid B.

A B

C D

Figure 6. LC-MS TIC diagram positive and negative ion modes for DSY and its individual herbs. (A) DSY. (B) DS. (C) SR. (D) TX.
Abbreviations: DS: Salvia miltiorrhiza Bge.; DSY: Dan-Shen-Yin; LC-MS: Liquid chromatography–mass spectrometry; NEG: Negative ion mode; POS:
Positive ion mode; SR: Amomum villosum Lour.; TIC: Total ion chromatogram; TX: Santalum album L.
inflammatory, antioxidant, antitumor, and antimetastatic in the treatment of gastritis and the prevention of gastric
properties. Moreover, DS extract may serve as a potential cancer.
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chemopreventive agent against bile reflux-associated gastric
cancer. Danshensu, a major compound of DS extract, has 3.5. Measurement and analysis of polysaccharides in
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been shown to prevent bile reflux-induced gastritis and DSY decoction
gastric cancer by modulating multiple signaling pathways The contents of total sugar, uronic acid, and protein in
involved in inflammation, oxidative stress, DNA damage, DSY decoction and its individual herbs (DS, TX, and SR)
and apoptosis. Collectively, these findings underscore are summarized in Figure 7. The sugar content in DSY
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the significant role of DS-derived nonvolatile compounds was 45.70%, as determined using the phenol-sulfuric acid

Volume 9 Issue 3 (2025) 175 doi: 10.36922/EJMO025160124