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Eurasian Journal of
Medicine and Oncology WGCNA and LASSO for osteoporosis biomarkers
A B
Figure 5. Machine learning screening using LASSO regression model. (A) The coefficient profiles were plotted based on the log (lambda) sequence. (B) A
10-fold CV plot for optimal λ selection.
Abbreviations: CV: Cross-validation; LASSO: Least Absolute Shrinkage and Selection Operator.
A B C
D E F
G
Figure 6. Validation of hub gene expression in the GSE35958 dataset. Differential analysis of (A) LOC286177, (B) NUCB1, (C) PEX19, (D) MTA1,
(E) DRAP1, (F) PCDHGA1, and (G) PRPF39 expresison between healthy and OP groups. Group description: N, normal group; T, test group comprising
osteoporosis (OP) patients.
Abbreviations: NUCB1: Nucleobindin 1; PEX19: Peroxisomal biogenesis factor 19; MTA1: Metastasis associated 1; DRAP1: DRA aassociated protein 1;
PCDHGA1: Protocadherin gamma A1; PRPF39: Pre-mRNA processing factor 39.
Volume 9 Issue 3 (2025) 269 doi: 10.36922/EJMO025240252
