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Gene & Protein in Disease m1A-mediated ESCCAL-1 promotes ESCA stemness

Recent studies have reported that the demethylase References
ALKBH3 can alter the post-transcriptional level of 1. Sung H, Ferlay J, Siegel RL, et al., 2021, Global cancer
oncogenic mRNAs and tRNAs by erasing m A modification statistics 2020: GLOBOCAN estimates of incidence and
1
and thus participate in tumor progression [14,15,29,30] . mortality worldwide for 36 cancers in 185 countries. CA
However, whether lncRNAs can also be regulated by m A Cancer J Clin, 71(3): 209–249.
1
modification is unknown. This study revealed that ALKBH3
caused ESCCAL-1 overexpression in ESCA through m A https://doi.org/10.3322/caac.21660
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demethylation modification. Significantly, ALKBH3 is 2. Bray F, Ferlay J, Soerjomataram I, et al., 2018, Global cancer
involved in the stemness maintenance of ESCA in an statistics 2018: GLOBOCAN estimates of incidence and
ESCCAL-1-dependent manner. This is the first report on mortality worldwide for 36 cancers in 185 countries. CA
the biological role of lncRNA m A modification in ESCA, Cancer J Clin, 68(6): 394–424.
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expanding our understanding on the role of lncRNA post- https://doi.org/10.3322/caac.21492
transcriptional modification in the development of ESCA. 3. Smyth EC, Lagergren J, Fitzgerald RC, et al., 2017,

5. Conclusions Oesophageal cancer. Nat Rev Dis Primers, 3: 17048.
https://doi.org/10.1038/nrdp.2017.48
This study further explored the expression of ESCCAL-1
in ESCA and its relationship with the clinical parameters 4. Song Y, Li L, Ou Y, et al., 2014, Identification of genomic
of patients. High expression of ESCCAL-1 is necessary to alterations in oesophageal squamous cell cancer. Nature,
509(7498): 91–95.
maintain the stemness status of ESCA. ALKBH3 promoted
the overexpression of ESCCAL-1 in an m A-dependent https://doi.org/10.1038/nature13176
1
manner. These findings provide a new strategy for clinically 5. Cui Y, Chen H, Xi R, et al., 2020, Whole-genome sequencing
targeting the ALKBH3/ESCCAL-1 axis against ESCA. of 508 patients identifies key molecular features associated
with poor prognosis in esophageal squamous cell carcinoma.
Acknowledgments Cell Res, 30(10): 902–913.
None. https://doi.org/10.1038/s41422-020-0333-6

Funding 6. Xi Y, Lin Y, Guo W, et al., 2022, Multi-omic characterization
of genome-wide abnormal DNA methylation reveals
This study was supported by the Medical Science and diagnostic and prognostic markers for esophageal
Technology Project of Henan Province (LHGJ20200765, squamous-cell carcinoma. Signal Transduct Target Ther,
SB201903032, SBGJ202003053) and the Key Project of 7(1): 53.
Higher Education in Henan Province (20A310018). https://doi.org/10.1038/s41392-022-00873-8
Conflict of interest 7. Slack FJ, Chinnaiyan AM, 2019, The role of non-coding
RNAs in oncology. Cell, 179(5): 1033–1055.
The authors declare that there are no competing interests.
https://doi.org/10.1016/j.cell.2019.10.017
Author contributions 8. Cao W, Lee H, Wu W, et al., 2020, Multi-faceted epigenetic
dysregulation of gene expression promotes esophageal
Conceptualization: Wei Cao squamous cell carcinoma. Nat Commun, 11(1): 3675.
Formal analysis: Yuanbo Cui
Investigation: Yuanbo Cui, Yanan Lou, Pengju Lv https://doi.org/10.1038/s41467-020-17227-z
Writing – original draft: Yuanbo Cui 9. Liu J, Mayekar MK, Wu W, et al., 2020, Long non-coding
Writing – review & editing: Wei Cao RNA ESCCAL-1 promotes esophageal squamous cell
carcinoma by down regulating the negative regulator of
Ethics approval and consent to participate APOBEC3G. Cancer Lett, 493: 217–227.
Not applicable. https://doi.org/10.1016/j.canlet.2020.09.001
10. Cui Y, Yan M, Wu W, et al., 2022, ESCCAL-1 promotes
Consent for publication cell-cycle progression by interacting with and stabilizing
Not applicable. galectin-1 in esophageal squamous cell carcinoma. NPJ
Precis Oncol, 6(1): 12.
Availability of data https://doi.org/10.1038/s41698-022-00255-x
The data are available from the corresponding author upon 11. Jin H, Huo C, Zhou T, et al., 2022, m A RNA modification in
1
reasonable request. gene expression regulation. Genes (Basel), 13(5): 910.

Volume 2 Issue 1 (2023) 9 https://doi.org/10.36922/gpd.305