Page 83 - GPD-2-1

Gene & Protein in Disease

ORIGINAL RESEARCH ARTICLE
A pan-cancer analysis of high mobility group

box 1 and its role in human tumorigenesis

1
Wenqing Long , Jiaqi Li , Hao Shi , Lijun Zhang , Liqun Yang , Zhuoyan Jiang ,
1
1
1
3
1
1
Lei Xia , Lin Wang *, and Hongnu Yu *
2
1
1 Department of Thoracic Surgery, Affiliated Xinhua Hospital of Dalian University, Dalian, Liaoning
province, China
2 Department of Oncology, Affiliated Xinhua Hospital of Dalian University, Dalian, Liaoning province,
China
3 Department of Special Examination, Shaoxing People’s Hospital, Shaoxing, Zhejiang province,
China
Abstract
Understanding the specific and co-driving mechanisms of carcinogenesis in human
tumors is indispensable for cancer research and can guide the development of effective
treatment methods for tumors. High mobility group box 1 (HMGB1) participates in a
variety of physiological processes of the body and has an inseparable relationship with
tumors. In this study, The Cancer Genome Atlas, Gene Expression Omnibus database,
Human Protein Atlas, and bioinformatic tools were used to conduct pan-cancer analysis of
HMGB1 in various cancers so as to elucidate its role in human tumorigenesis. We analyzed
and evaluated the expression of HMGB1 in tumors, and discovered that overexpression
of HMGB1 usually indicated poor overall survival of adrenocortical carcinoma (P < 0.01)
and lung adenocarcinoma (LUAD) (P < 0.05). High HMGB1 expression is also associated
with unfavorable disease-free survival for patients with adrenocortical carcinoma (P <
*Corresponding authors:
Lin Wang 0.001), cervical squamous cell carcinoma and endocervical adenocarcinoma (P < 0.01),
(wanglinbox@sina.com) head and neck squamous cell carcinoma (P < 0.05), LUAD (P < 0.05), and sarcoma (P <
Hongnu Yu 0.05). The potential mechanism of HMGB1-mediated tumorigenesis is also discussed.
(879187182@qq.com) In conclusion, our pan-cancer analysis offers a comprehensive description of the
Citation: Long W, Li J, Shi H, et al., carcinogenic roles of HMGB1 in a variety of human cancers.
2023, A pan-cancer analysis of
high mobility group box 1 and its
role in human tumorigenesis. Gene Keywords: High mobility group box 1; Cancer; Survival; Prognosis
Protein Dis, 2(1):301.
https://doi.org/10.36922/gpd.301
Received: December 15, 2022
Accepted: March 1, 2023
Published Online: March 16, 2023 1. Introduction
Copyright: © 2023 Author(s). In view of the complexity of tumorigenesis, it is vital to conduct a pan-cancer analysis
This is an Open Access article of the significant genes to evaluate their relevance to possible molecular mechanisms
distributed under the terms of the
Creative Commons Attribution and clinical prognosis. Cancer genome repositories and databases, such as The
License, permitting distribution, Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), offer access to
and reproduction in any medium, many tumor-associated functional genomic datasets that can be used for pan-cancer
provided the original work is
properly cited. analysis [1-3] .
Publisher’s Note: AccScience Situated on chromosome 13q12, the high mobility group box 1 (HMGB1) gene
Publishing remains neutral with encodes and produces the HMGB1 protein , which is a highly conserved nuclear
[4]
regard to jurisdictional claims in
published maps and institutional protein belonging to the group of nonhistone chromatin-related protein. It was first
affiliations. extracted from the bovine thymus in 1973 . HMGB1 consists of two DNA-binding
[5]
Volume 2 Issue 1 (2023) 1 https://doi.org/10.36922/gpd.301