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Gene & Protein in Disease SCN7A is a protective factor in LUAD

A B

C
D

Figure 1. Identification of differentially expressed genes (DEGs) between lung adenocarcinoma and normal tissues from GEO datasets. (A–B) Volcano plot
and heatmap of 267 DEGs. (C) Gene ontology enrichment analysis results inclusive of MF, BP, and CC. (D) Kyoto Encyclopedia of Genes and Genomes
pathway enrichment analysis results.
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C D E

Figure 2. Expression and prognostic analysis of candidate genes. (A) Venn diagram showing five differentially expressed gene (DEGs) overlapping with ion
channel-related genes (B) Expression analysis of five candidate genes using the lung adenocarcinoma (LUAD) data in The Cancer Genome Atlas (TCGA):
GRIA1 (P = 7.98e-34), CLIC5 (P = 1.88e-35), KCNT2 (P = 1.24e-32), SCN7A (P = 8.10e-31), and CACNA2D2 (P = 2.03e-29). (C–E) Prognostic value of
GRIA1, SCN7A, and CACNA2D2 for LUAD using the LUAD data in TCGA.
Volume 2 Issue 1 (2023) 4 https://doi.org/10.36922/gpd.363