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Global Translational Medicine Influence of ferroptosis in neurological diseases

Figure 3. The protein–protein interaction network for Parkinson’s disease (PD protein–protein interaction networks) consists of 819 nodes and 4766 edges.
during later stages of AD . C5AR1 encodes a proinflammatory Thus, the DEGs we identified represent genes that play
[34]
receptor for C5a, with C5aR1 antagonists found to protect crucial roles in disease progression. Moreover, we found 21
against the onset of AD . DEGs that were common to both AD and PD (Figure 1).
[35]
To identify DEGs for PD, we analyzed gene expression 3.2. Detection of hub genes from functional
data from GSE106608 and examined gene expression modules in AD and PD PPIN
changes in STN from post-mortem brains of PD patients. The results indicate that ferroptosis may play a role
By applying cutoff values of log FC > 1.0 and adjusted P in instigating the progression of both AD and PD.
2
< 0.05 (Table S2), 122 DEGs were identified. Significant Reconstruction of PPIN with direct interactors of DEGs
DEGs associated with PD included NEAT1, CASP7, and provides a comprehensive view of molecular signaling events
SERPINA1. NEAT1 is known to initiate the formation of and the diverse pathways involved in disease progression .
[39]
nuclear paraspeckles, which are involved in the progression Thus, we initially reconstructed two separate PPINs for AD
of PD. It has been proposed to be a possible biomarker for and PD using STRING v11 API in Python 3.9.2., considering
PD . CASP7 encodes caspase-7, which has been found only physical interactions with a confidence score >0.7 .
[36]
[40]
to promote the activation of microglia and lead to The resulting networks were then visualized in Cytoscape
[37]
neurotoxicity and neurodegeneration. SERPINA1, which v3.9.1 (Figures 2 and 3). The PPIN for AD (AD-PPIN)
[24]
encodes serpina1 protein, has modified forms associated consists of 1478 nodes and 13344 edges (Figure 2), while the
with dementia in PD . PPIN for PD (PD-PPIN) consists of 819 nodes and 4766 edges
[38]
Volume 2 Issue 3 (2023) 5 https://doi.org/10.36922/gtm.0318