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Global Translational Medicine                                   Influence of ferroptosis in neurological diseases



            transcription factors during the pathogenesis of these two   homeostasis and oxidative stress: An intimate relationship.
            neurodegenerative  diseases.  Thus,  this  study  identifies   Biochim Biophys Acta Mol Cell Res, 1866: 118535.
            potential ferroptosis markers that may play a driving role      https://doi.org/10.1016/j.bbamcr.2019.118535
            in these diseases. Finally, we have devised therapeutic
            measures that can be experimentally tested for their   3.   Reichert CO, de Freitas FA, Sampaio-Silva J,  et al., 2020,
                                                                  Ferroptosis  mechanisms  involved in  neurodegenerative
            efficacy in combating ferroptosis in AD and PD. This study   diseases. Int J Mol Sci, 21: 8765.
            provides valuable insights for experimental biologists to
            use these ferroptosis markers and demystify their mode of      https://doi.org/10.3390/ijms21228765
            action  in  causing  neurodegeneration,  thereby  advancing   4.   Xu Y, Zhao J, Zhao Y, et al., 2023, The role of ferroptosis in
            our understanding of these diseases.                  neurodegenerative diseases. Mol Biol Rep, 50: 1655–1661.

            Acknowledgments                                       https://doi.org/10.1007/s11033-022-08048-y
                                                               5.   Chen X, Yu C, Kang R,  et  al., 2020, Iron metabolism in
            This research is an outcome of the autonomous research   ferroptosis. Front Cell Dev Biol, 8: 590226.
            group “Ethophilia.” We thank all the members for their
            constant support and enthusiasm.                      https://doi.org/10.3389/fcell.2020.590226
                                                               6.   Munshi C, Bhattacharya S, 2022, The “irony” of ferroptosis:
            Funding                                               A review on neurological challenges. In: Xu K, editor. Cell
            This research did not receive any specific grant from   Death and Disease. Rijeka: IntechOpen.
            funding agencies in the public, commercial, or not-for-     https://doi.org/10.5772/intechopen.108737
            profit sectors.                                    7.   Ou M, Jiang Y, Ji Y,  et al., 2022, Role and mechanism of
                                                                  ferroptosis in neurological diseases. Mol Metab, 61: 101502.
            Conflict of interest
                                                                  https://doi.org/10.1016/j.molmet.2022.101502
            The authors declare no conflict of interest with any
            organization or financial entity.                  8.   Yan H, Zou T, Tuo Q, et al., 2021, Ferroptosis: Mechanisms
                                                                  and links with diseases. Signal Transduct Target Ther, 6: 49.
            Author contributions                                  https://doi.org/10.1038/s41392-020-00428-9
            Conceptualization: Deepyaman Das, Chayan Munshi    9.   Ma H, Dong Y, Chu Y,  et  al., 2022, The mechanisms of
            Formal analysis: Deepyaman Das                        ferroptosis  and  its  role  in  Alzheimer’s  disease.  Front Mol
            Investigation: Deepyaman Das, Chayan Munshi           Biosci, 9: 965064.
            Methodology: Deepyaman Das                            https://doi.org/10.3389/fmolb.2022.965064
            Writing – original draft:  Deepyaman  Das,  Kalpesh  Jas,   10.  Ward RJ, Zucca FA, Duyn JH, et al., 2014, The role of iron
               Sourish Pramanik                                   in brain ageing and neurodegenerative disorders.  Lancet
            Writing – review & editing: Deepyaman Das, Chayan     Neurol, 13: 1045–1060.
               Munshi
                                                                  https://doi.org/10.1016/S1474-4422(14)70117-6
            Ethics approval and consent to participate         11.  Zhang Y, Wang M, Chang W, 2022, Iron dyshomeostasis and

            Not applicable.                                       ferroptosis in Alzheimer’s disease: Molecular mechanisms of
                                                                  cell death and novel therapeutic drugs and targets for AD.
            Consent for publication                               Front Pharmacol, 13: 983623.

            Not applicable.                                       https://doi.org/10.3389/fphar.2022.983623
                                                               12.  Yang WS, Kim KJ, Gaschler MM, et al., 2016, Peroxidation
            Availability of data                                  of polyunsaturated fatty acids by lipoxygenases drives

            All the data used in the study are publicly available.  ferroptosis. Proc Natl Acad Sci U S A, 113: E4966–E4975.
                                                                  https://doi.org/10.1073/pnas.1603244113
            References
                                                               13.  Chen K, Jiang X, Wu M, et al., 2021, Ferroptosis, a potential
            1.   Sun Y, Chen P, Zhai B,  et  al., 2020, The emerging role   therapeutic target in Alzheimer’s disease.  Front Cell Dev
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            Volume 2 Issue 3 (2023)                         11                       https://doi.org/10.36922/gtm.0318
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