Page 87 - GTM-3-3

Global Translational Medicine

BRIEF REPORT
Non-surgical treatment of periodontal intrabony

defects using rhPDGF-BB-saturated collagen
sponges

Thaer Alqadoumi 1 , Fatemeh SamavatiJame 2,3 , Noor Daras 4 ,and

Muhammad H. A. Saleh *
2
1 Department of Periodontics, School of Dentistry, University of Loma Linda, Loma Linda, California,
United States of America
2 Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann
Arbor, Michigan, United States of America
3 Department of Periodontics and Oral Medicine, School of Dentistry, Nova Southeastern University,
Fort Lauderdale, United States of America
4 Department of General Dentistry, School of Dentistry, University of Southern California, Los
Angeles, California, United States of America

Abstract

This study evaluated the use of a collagen sponge soaked with recombinant human
platelet-derived growth factor-BB for non-surgical treatment of intrabony defects
in the esthetic zone. After 6 months of follow-up, this technique demonstrated
positive outcomes, including reduced probing depth and improved attachment
levels, indicative of periodontal regeneration. The notable improvement in clinical
parameters indicates that this approach could be a viable non-surgical alternative
*Corresponding author: with clinical outcomes comparable to current surgical procedures.
Muhammad H. A. Saleh
(muhsaleh@umich.edu)
Citation: Alqadoumi T, Keywords: Periodontal regeneration; Esthetic; Recombinant human platelet-derived
SamavatiJame F, Daras N, Saleh growth factor-BB

MHA. Non-surgical treatment of
periodontal intrabony defects using
rhPDGF-BB-saturated collagen
sponges. Global Transl Med.
2024:3(3):3313. 1. Introduction
doi: 10.36922/gtm.3313
Periodontal therapy aims to address inflammation, prevent disease progression, and
Received: March 29, 2024
1
Accepted: May 28, 2024 restore the lost attachment apparatus. Both non-surgical and surgical approaches can
Published Online: September 4, 2024 be effective, with each demonstrating positive outcomes. Non-surgical treatments, such
Copyright: © 2024 Author(s). as subgingival scaling, root planing, and subgingival curettage have resulted in reduced
This is an Open-Access article probing depths (PD) and increased clinical attachment levels (CAL). Recombinant
2
distributed under the terms of the
Creative Commons Attribution human platelet-derived growth factor-BB (rhPDGF-BB) has been extensively studied in
License, permitting distribution, periodontics and is known to promote the growth of bone, cementum, and periodontal
and reproduction in any medium, ligament. 3
provided the original work is
properly cited. Although periodontal regeneration can be achieved without biological materials,
Publisher’s Note: AccScience studies have highlighted the beneficial effects of rhPDGF-BB in enhancing cellular
Publishing remains neutral with functions such as growth and chemotaxis, thereby facilitating periodontal regeneration.
4,5
regard to jurisdictional claims in
published maps and institutional Recent research also supports the positive impact of rhPDGF-BB on hard and soft tissue
affiliations. rejuvenation, promoting periodontal regeneration in various applications. 6

Volume 3 Issue 3 (2024) 1 doi: 10.36922/gtm.3313