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Global Translational Medicine Rapid diagnostic imaging on biopsy needle

Eliminating the need for a clean glass surface would Acknowledgments
streamline the imaging process. Integrating FIBI thick
tissue imaging, which can produce a 30× greater signal- We extend our gratitude to Dr. Farzad Fereidouni at the
to-noise ratio compared to MUSE images, can accelerate University of California, Davis, for his pioneering work
the imaging process and eliminate UV optical hazards, as in MUSE imaging and his invaluable contributions to
well as the need for expensive quartz glass. Although the the development of the CoreView ION system. Dr. Jane
extended depth of focus algorithm would eliminate the Brock provided the photograph taken of the CNB
need for tissue compression, its deployment requires fast procedure using a reusable biopsy gun. We appreciate
axial scanning, which would increase cost and complexity the input of Dr. Beatrice Wiafe Addai for insightful
for the future portable CoreView ION system. While these discussions on the global needs for rapid BC diagnosis at
technological adaptations are promising for low-resource the bedside and the unmet need for a low-cost portable
and point-of-care applications, clinical translation CoreView system for more rural healthcare clinics in
will ultimately require validation using human biopsy West Africa.
specimens to confirm clinical diagnostic accuracy and Funding
performance. Expanding accessibility and accelerating
diagnosis with AI-enhanced analysis of thick tissue biopsy This research was made possible through financial support
images are within reach, as these pre-clinical results suggest from the National Cancer Institute of the National Institutes
that the CoreView instrument can provide rapid, point-of- of Health under grants R21CA246359 and R33CA278544,
care diagnosis for the most prevalent cancers in Africa: BC, awarded through the Innovative Molecular Analysis
cervical cancer, and prostate cancer. 28-32 Technologies program, as well as grant U01CA269191.
The MUSE microscope and camera were purchased from
4. Conclusion early-phase translational grants (S2019_SEIBEL_7268)

The CoreView ION system demonstrates the feasibility from UW Commotion and the Washington Research
of rapid, on-needle imaging for CNB analysis, offering Foundation, Seattle, Washington.
a potential low-cost point-of-care solution for BC Conflict of interest
diagnostics. By integrating MUSE imaging with a more
streamlined workflow, this system enables bedside Matthew D. Carson and Eric J. Seibel are co-authors of a
visualization of biopsy samples, compared to the days patent owned by the UW. They are also the participants in
to months of delays experienced now in low-resource the royalty-sharing program.
settings. Further optimization and clinical validation with
human tissue will be necessary to fully establish its role in Author contributions
improving BC survival rates by providing greater access to Conceptualization: Eric J. Seibel, Matthew D. Carson
these new rapid diagnostic pathways. This approach is a Investigation: Jocelyn R. Jensen, Duy Do, Yuan-ping Chang,
significant advancement in pathology, using thick tissue Suzanne Dintzis, Richard M. Levenson
biopsy imaging (MUSE and FIBI), as on-needle imaging Methodology: All authors
has not been previously explored. By enabling real-time Writing–original draft: Jocelyn R. Jensen
evaluation at the point of care, the CoreView ION system Writing–review & editing: Eric J. Seibel, Matthew D.
has the potential to greatly reduce patient burden, expedite Carson, Suzanne Dintzis, Richard M. Levenson
treatment decisions, and ultimately improve clinical
outcomes in BC diagnostics. Ethics approval and consent to participate

Supplemental information De-identified human prostate tissue images were provided
by the University of California, Davis, under Institutional
Video S1. Video demonstration of the CoreView imaging Review Board exemption FWA No: 00004557, granted
on needle concept. The objective lens is focused on the top on June 23, 2023. The exemption was issued under the
surface of the compressed tissue that rests on the coring supervision of Principal Investigator Dr. Richard Levenson.
needle. Only the contacting parts (mechanical extension As all samples were de-identified before transfer, informed
of the objective lens and the small specimen chamber) are consent was not required in accordance with institutional
shown in cross-section. and federal guidelines.
Video S2. Video demonstration of CoreView imaging on Consent for publication
needle workflow with animated computer-aided design
drawings. Not applicable.

Volume 4 Issue 3 (2025) 116 doi: 10.36922/GTM025170039