Page 144 - IJB-10-3

International Journal of Bioprinting New challenges in liver tissue engineering

63. Gomez-Lechon M, Donato M, Lahoz A, Castell J. Cell 74. Donato MT, Tolosa L, Gómez-Lechón MJ. Culture and
lines: a tool for in vitro drug metabolism studies. Curr Drug functional characterization of human hepatoma HepG2
Metab. 2008;9(1):1-11. cells. Methods Mol Biol. 2015;1250:77-93.
doi: 10.2174/138920008783331086 doi: 10.1007/978-1-4939-2074-7_5
64. Hewitt NJ, Gómez Lechón MJ, Houston JB, et al. Primary 75. Forbes SJ, Gupta S, Dhawan A. Cell therapy for liver
hepatocytes: current understanding of the regulation disease: from liver transplantation to cell factory. J Hepatol.
of metabolic enzymes and transporter proteins, and 2015;62(1):S157-S169.
pharmaceutical practice for the use of hepatocytes in doi: 10.1016/j.jhep.2015.02.040
metabolism, enzyme induction, transporter, clearance, and 76. Donato MT, Tolosa L. Stem-cell derived hepatocyte-
hepatotoxicity studies. Drug Metab Rev. 2007;39(1):159-234. like cells for the assessment of drug-induced liver injury.
doi: 10.1080/03602530601093489 Differentiation. 2019;106(January):15-22.
65. O´Brien PJ, Chan K, Silber PM. Human and animal doi: 10.1016/j.diff.2019.02.004
hepatocytes in vitro with extrapolation in vivo. Chem Biol 77. Hannan NRF, Segeritz CP, Touboul T, Vallier L. Production
Interact. 2004;150(1):97-114. of hepatocyte-like cells from human pluripotent stem cells.
doi: 10.1016/j.cbi.2004.09.003 Nat Protoc. 2013;8(2):430-437.
66. O´Brien PJ, Irwin W, Diaz D, et al. High concordance doi: 10.1038/nprot.2012.153
of drug-induced human hepatotoxicity with in vitro 78. Takayama K, Morisaki Y, Kuno S, et al. Prediction
cytotoxicity measured in a novel cell-based model using of interindividual differences in hepatic functions
high content screening. Arch Toxicol. 2006;80(9):580-604. and drug sensitivity by using human iPS-derived
doi: 10.1007/s00204-006-0091-3 hepatocytes. Proc Natl Acad Sci. 2014;111(47):
67. Tolosa L, Pareja-Ibars E, Donato MT, et al. Neonatal livers: a 16772-16777.
source for the isolation of good-performing hepatocytes for doi: 10.1073/pnas.1413481111
cell transplantation. Cell Transplant. 2014;23(10):1229-1242. 79. Bell CC, Dankers ACA, Lauschke VM, et al. Comparison
doi: 10.3727/096368913X669743 of hepatic 2D sandwich cultures and 3d spheroids for long-
68. Gomez-Lechon M, Donato M, Castell J, Jover R. Human term toxicity applications: a multicenter study. Toxicol Sci.
hepatocytes in primary culture: the choice to investigate drug 2018;162(2):655-666.
metabolism in man. Curr Drug Metab. 2004;5(5):443-462. doi: 10.1093/toxsci/kfx289
doi: 10.2174/1389200043335414 80. Lee JY, Han HJ, Lee SJ, et al. Use of 3D human liver organoids
69. Chowdhary V, Teng K yu, Thakral S, et al. miRNA-122 to predict drug-induced phospholipidosis. Int J Mol Sci.
protects mice and human hepatocytes from acetaminophen 2020;21(8):2982.
toxicity by regulating cytochrome P450 family 1 subfamily doi: 10.3390/ijms21082982
A member 2 and family 2 subfamily e member 1 expression. 81. Berger M, Neth O, Ilmer M, et al. Hepatoblastoma cells
Am J Pathol. 2017;187(12):2758-2774. express truncated neurokinin-1 receptor and can be growth
doi: 10.1016/j.ajpath.2017.08.026 inhibited by aprepitant in vitro and in vivo. J Hepatol.
70. Fox IJ, Chowdhury JR. Hepatocyte transplantation. Am J 2014;60(5):985-994.
Transplant. 2004;4:7-13. doi: 10.1016/j.jhep.2013.12.024
doi: 10.1111/j.1600-6135.2004.0340.x 82. Davidson MD, Pickrell J, Khetani SR. Physiologically
71. Hansel MC, Davila JC, Vosough M, et al. The use of induced inspired culture medium prolongs the lifetime and insulin
pluripotent stem cells for the study and treatment of liver sensitivity of human hepatocytes in micropatterned co-
diseases. Curr Protoc Toxicol. 2016;67(1). cultures. Toxicology. 2021;449.
doi: 10.1002/0471140856.tx1413s67 doi: 10.1016/j.tox.2020.152662
72. Iansante V, Mitry RR, Filippi C, Fitzpatrick E, Dhawan A. 83. Takebe T, Sekine K, Enomura M, et al. Vascularized and
Human hepatocyte transplantation for liver disease: current functional human liver from an iPSC-derived organ bud
status and future perspectives. Pediatr Res. 2018;83(1- transplant. Nature. 2013;499(7459):481-484.
2):232-240. doi: 10.1038/nature12271
doi: 10.1038/pr.2017.284 84. Peters JT, Wechsler ME, Peppas NA. Advanced biomedical
73. Gómez-Lechón MJ, Tolosa L, Conde I, Donato MT. hydrogels: molecular architecture and its impact on medical
Competency of different cell models to predict human applications. Regen Biomater. 2021;8(6).
hepatotoxic drugs. Expert Opin Drug Metab Toxicol. doi: 10.1093/rb/rbab060
2014;10(11):1553-1568. 85. Annabi N, Tamayol A, Uquillas JA, et al. 25th anniversary
doi: 10.1517/17425255.2014.967680 article: rational design and applications of hydrogels in

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