Page 149 - IJB-10-3

International

Journal of Bioprinting

REVIEW ARTICLE
3D-bioprinted bone for regenerative medicine:

Current concepts and future perspectives

Borbála Lovászi 1,2,3 , Diána Szűcs 1,2,3 , Tamás Monostori ,
1,3
Lajos Kemény 1,3,4,5 , and Zoltán Veréb 1,3,4 *
1 Regenerative Medicine and Cellular Pharmacology Laboratory, Department of Dermatology and
Allergology, University of Szeged, Szeged, Hungary
2 Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary
3 Interdisciplinary Research Development and Innovation, Center of Excellence, University of
Szeged, Szeged, Hungary
4 Research Institute of Translational Biomedicine, Department of Dermatology and Allergology,
University of Szeged, Szeged, Hungary
5 Hungarian Centre of Excellence for Molecular Medicine-University of Szeged Skin Research
Group (HCEMM-USZ Skin Research Group), University of Szeged, Szeged, Hungary

Abstract
The shortages in human tissue and organ donors have made clinical therapy
relatively challenging. Therefore, research has been initiated over the last decades to
develop artificial tissues and organs, particularly from cell and tissue cultures. Three-
dimensional (3D) bioprinting is a recent technology capable of building structures
for implantation, and these constructs closely resemble native tissues, such as skin,
liver, connective tissues, and supportive tissues (bone and cartilage). In this review,
we briefly introduce the structure, function, and development of bone tissues,
*Corresponding author: followed by a detailed discussion on 3D bioprinting techniques, materials, and their
Zoltán Veréb
(vereb.zoltan@med.u-szeged.hu) recent advancements for clinical applications.
Citation: Lovászi B, Szűcs D,
Monostori T, Kemény L, Veréb Z. Keywords: Bone; 3D bioprinting; Transplantation; Therapy; Clinical use;
3D-bioprinted bone for regenerative
medicine: current concepts and Regenerative medicine
future perspectives. Int J Bioprint.
2024;10(3):2056.
doi: 10.36922/ijb.2056
Received: October 17, 2023 1. Introduction
Accepted: February 21, 2024
Published Online: June 12, 2024 Bone is a vital organ that constitutes the body’s skeletal framework, enabling movement
and providing essential protection for internal organs. Bone replacement and
Copyright: © 2024 Author(s).
This is an Open Access article supplementation are indispensable in treating various bone-related physical injuries
distributed under the terms of the and pathological conditions (e.g., tumors and autoimmune diseases). However, the
Creative Commons Attribution complexity of bone structures and their physicomechanical properties convolutes the
License, permitting distribution,
1-4
and reproduction in any medium, therapeutic efficacy of general bone replacement procedures. Three-dimensional (3D)
provided the original work is bioprinting has emerged as a promising technology in tissue engineering to synthesize
properly cited.
biologically similar tissue structures from suitable materials (e.g., hydrogels and cells)
5,6
Publisher’s Note: AccScience (Figure 1). The printed constructs initially undergo incubation and maintenance
Publishing remains neutral with to induce tissue formation, followed by rigorous morphological, mechanical, and
regard to jurisdictional claims in
published maps and institutional biological tests for standardization. Thereafter, successfully 3D-bioprinted tissues may
affiliations.

Volume 10 Issue 3 (2024) 141 doi: 10.36922/ijb.2056